FDA Enforcement Class III Terminated

Cobas KRAS Mutation Test for In Vitro Diagnostic Use Product Usage: Usage: The Cobas KRAS Mutation Test, for use with the Cobas 4800 System, is a real-time PCR test intended for the identification of mutations in codons 12, 13 and 61 of the KRAS gene in DNA derived from formalin-fixed paraffin-embedded human colorectal cancer (CRC).

Recall: Z-2159-2012 · Reported August 15, 2012

Enforcement

Recall Number
Z-2159-2012
Event ID
62500
Classification
Class III
Status
Terminated
Product Type
Devices
Firm
Roche Molecular Systems, Inc.
Voluntary / Mandated
Voluntary: Firm initiated
Initial Notification
E-Mail
Report Date
August 15, 2012
Initiation Date
February 24, 2012
Classification Date
August 8, 2012
Termination Date
July 16, 2013
Address
1080 Us Highway 202 S, Branchburg, NJ, 08876-3733, United States

Description

Cobas KRAS Mutation Test for In Vitro Diagnostic Use Product Usage: Usage: The Cobas KRAS Mutation Test, for use with the Cobas 4800 System, is a real-time PCR test intended for the identification of mutations in codons 12, 13 and 61 of the KRAS gene in DNA derived from formalin-fixed paraffin-embedded human colorectal cancer (CRC).

Reason

During the real-time stability testing for the cobas KRAS Mutation Test on the commercial lot PO6778, it was identified that the kit was just within specifications for the codon 61 peak height ratio, and that the kit has trended towards the upper specification limit at the 6 month time point but did passed the 6 month stability testing. The kit is labeled for 9 months shelf life stability. The d

Code Info

05852170190; Lot P06778

Distribution

Worldwide Distribution - including the countries of Austria, Belgium, Czech Republic, Denmark, Germany, Italy, Luxemburg, Netherlands, Poland, Slovakia, Slovenia, Spain, United Kingdom, Canada, Chile, Greenland, Hong Kong, Israel, Malaysia, New Zealand, Philippines, S. Africa, Switzerland, Taiwan and Turkey.

Quantity

264 kits to 13 EU countries; 2 kits to Canada and 33 kits to 11 countries in the Rest of the World