FDA Adverse Event Injury Summary report: N

AFX

MDR report key: 7549905 · Received May 29, 2018

Report

Report Number
2031527-2018-00487
Event Type
Injury
Date Received
May 29, 2018
Date of Event
December 11, 2017
Report Date
May 29, 2018
Manufacturer
ENDOLOGIX INC.
Product Code
MIH
UDI-DI
0081009013620
PMA / PMN Number
P040002
Adverse Event
Yes
Product Problem
Yes
Report Source
Manufacturer report
Reporter Location
VA, US
Reporter Occupation
PHYSICIAN

Narratives

Additional Manufacturer Narrative · 0

AT THE COMPLETION OF THE CLINICAL EVALUATION AND BASED ON THE INFORMATION RECEIVED, THERE WAS SUBSTANTIAL EVIDENCE TO SUPPORT THE FOLLOWING REPORTED EVENTS: ENDOLEAKS 1A AND 2, AND ENDOVASCULAR RELINING. THERE WAS SUBSTANTIAL EVIDENCE TO REFUTE THE FOLLOWING REPORTED EVENTS: ENDOLEAK 3A, RATHER THERE WAS AN ENDOLEAK 3B NOTED ONE MONTH POST-IMPLANT (LEFT LATERAL DISTAL NEAR BIFURCATION). ADDITIONAL FINDINGS INCLUDE SAC GROWTH (8MM/27M) AT 27 MONTHS POST-IMPLANT. THE MOST LIKELY CAUSE OF THE PROXIMAL LOSS OF SEAL WAS THE HOSTILE AORTIC NECK ANATOMY AND THE PRESENCE OF A PATENT, LOW ACCESSORY RENAL ARTERY. THE MOST LIKELY CAUSE OF THE COMPROMISED STENT GRAFT INTEGRITY (BREACHED) OF THE MAIN BODY STENT WAS THE USE OF STRATA MATERIAL. PROCEDURE-RELATED HARMS INCLUDED A TYPE 2 ENDOLEAK. THE FINAL PATIENT DISPOSITION COULD NOT BE DETERMINED DUE TO THE LACK OF MEDICAL INFORMATION SURROUNDING THE IMPLANT AND REPAIR EVENTS. THE MANUFACTURING LOT REVIEW CONFIRMED ALL DEVICES MET SPECIFICATIONS PRIOR TO RELEASE. ENDOLOGIX CONTINUES TO INVESTIGATE THIS EVENT AND SIMILAR EVENTS TO ENSURE THE HIGHEST QUALITY AND PATIENT SAFETY. REFERENCE MANUFACTURER REPORT NUMBER 2031527-2018-00192 FOR FOLLOW-UP REPORT 001 TO AFX BIFURCATED STENT GRAFT, LOT # 1251692-025.THIS REPORT IS TO ADDRESS THE TYPE 1A ENDOLEAK FOUND AT CLINICAL EVALUATION TO AFX VELA SUPRARENAL, LOT # 1210034-013. A ROOT CAUSE INVESTIGATION WAS CARRIED OUT FOR ALL AFX COMPLAINTS HAVING AN IDENTIFIED FAILURE MODE OF A TYPE 3B ENDOLEAK. ENDOLOGIX IMPLEMENTED THE FOLLOWING CORRECTIVE ACTIONS WITH THE INTENT OF REDUCING TYPE 3B ENDOLEAK EVENTS; 1. UPGRADED GRAFT MATERIAL (I.E. DURAPLY) AND 2. UPDATES TO THE IFU AND ADDITIONAL PHYSICIAN TRAINING. THE CHANGE TO DURAPLY GRAFT MATERIAL AND THE IFU CHANGES WERE PUT IN PLACE JULY 2014. THE TYPE 3B ENDOLEAK RATE FOR AFX MANUFACTURED AND IMPLANTED BEFORE THESE CORRECTIVE ACTIONS WERE PUT IN PLACE IS TRENDING AT 2.5%. SINCE THE CORRECTIVE ACTIONS WERE IMPLEMENTED, THE TYPE 3B ENDOLEAK EVENTS REPORTED FOR AFX DEVICES HAS BEEN REDUCED TO <0.2%.

Additional Manufacturer Narrative · 0

AT THE COMPLETION OF THE CLINICAL EVALUATION AND BASED ON THE INFORMATION RECEIVED, THERE WAS SUBSTANTIAL EVIDENCE TO SUPPORT THE FOLLOWING REPORTED EVENTS: ENDOLEAKS 1A AND 2, AND ENDOVASCULAR RELINING. THERE WAS SUBSTANTIAL EVIDENCE TO REFUTE THE FOLLOWING REPORTED EVENTS: ENDOLEAK 3A, RATHER THERE WAS AN ENDOLEAK 3B NOTED ONE MONTH POST-IMPLANT (LEFT LATERAL DISTAL NEAR BIFURCATION). ADDITIONAL FINDINGS INCLUDE SAC GROWTH (8 MM/27M) AT 27 MONTHS POST-IMPLANT. THE MOST LIKELY CAUSE OF THE PROXIMAL LOSS OF SEAL WAS THE HOSTILE AORTIC NECK ANATOMY AND THE PRESENCE OF A PATENT, LOW ACCESSORY RENAL ARTERY. THE MOST LIKELY CAUSE OF THE COMPROMISED STENT GRAFT INTEGRITY (BREACHED) OF THE MAIN BODY STENT WAS THE USE OF STRATA MATERIAL. PROCEDURE-RELATED HARMS INCLUDED A TYPE 2 ENDOLEAK. THE FINAL PATIENT DISPOSITION COULD NOT BE DETERMINED DUE TO THE LACK OF MEDICAL INFORMATION SURROUNDING THE IMPLANT AND REPAIR EVENTS. THE MANUFACTURING LOT REVIEW CONFIRMED ALL DEVICES MET SPECIFICATIONS PRIOR TO RELEASE. ENDOLOGIX CONTINUES TO INVESTIGATE THIS EVENT AND SIMILAR EVENTS TO ENSURE THE HIGHEST QUALITY AND PATIENT SAFETY. REFERENCE MANUFACTURER REPORT NUMBER 2031527-2018-00192 FOR FOLLOW-UP REPORT 001 TO AFX BIFURCATED STENT GRAFT, LOT # 1251692-025. THIS REPORT IS TO ADDRESS THE TYPE 1A ENDOLEAK FOUND AT CLINICAL EVALUATION TO AFX VELA SUPRARENAL, LOT # 1210034-013. A ROOT CAUSE INVESTIGATION WAS CARRIED OUT FOR ALL AFX COMPLAINTS HAVING AN IDENTIFIED FAILURE MODE OF A TYPE 3B ENDOLEAK. ENDOLOGIX IMPLEMENTED THE FOLLOWING CORRECTIVE ACTIONS WITH THE INTENT OF REDUCING TYPE 3B ENDOLEAK EVENTS; UPGRADED GRAFT MATERIAL (I.E. DURAPLY) AND UPDATES TO THE IFU AND ADDITIONAL PHYSICIAN TRAINING. THE CHANGE TO DURAPLY GRAFT MATERIAL AND THE IFU CHANGES WERE PUT IN PLACE (B)(6) 2014. THE TYPE 3B ENDOLEAK RATE FOR AFX MANUFACTURED AND IMPLANTED BEFORE THESE CORRECTIVE ACTIONS WERE PUT IN PLACE IS TRENDING AT (B)(4). SINCE THE CORRECTIVE ACTIONS WERE IMPLEMENTED, THE TYPE 3B ENDOLEAK EVENTS REPORTED FOR AFX DEVICES HAS BEEN REDUCED TO <0.2%.

Description of Event or Problem · 0

ENDOLOGIX BECAME AWARE OF A RE-INTERVENTION ON (B)(6) 2017 AS REPORTED BY PHYSICIAN (B)(6). AS THE DATE OF EVENT IS UNKNOWN, THE BEST ESTIMATE (B)(6) 2017 WAS USED. THE PATIENT WAS ORIGINALLY IMPLANTED WITH AN AFX BIFURCATED STENT GRAFT AND VELA SUPRARENAL ON (B)(6) 2015 BY THE REPORTING PHYSICIAN. ON AN UNKNOWN DATE, THE PHYSICIAN SUSPECTED A 3A ENDOLEAK, WHICH WAS NOT CONFIRMED, AND POSSIBLE BILLOWING WITH A TYPE 2 ENDOLEAK. THE PATIENT WAS ASYMPTOMATIC. DURING RE-INTERVENTION, THE PATIENT WAS RELINED BY IMPLANTING AN AFX2 BIFURCATED STENT GRAFT AND ONE ADDITIONAL VELA SUPRARENAL ON (B)(6) 2017 BY PHYSICIAN (B)(6).

Description of Event or Problem · 0

ENDOLOGIX BECAME AWARE OF A RE-INTERVENTION ON (B)(6) 2017 AS REPORTED BY PHYSICIAN (B)(6). AS THE DATE OF EVENT IS UNKNOWN, THE BEST ESTIMATE (B)(6) 2017 WAS USED. THE PATIENT WAS ORIGINALLY IMPLANTED WITH AN AFX BIFURCATED STENT GRAFT AND VELA SUPRARENAL ON (B)(6) 2015 BY THE REPORTING PHYSICIAN. ON AN UNKNOWN DATE, THE PHYSICIAN SUSPECTED A 3A ENDOLEAK, WHICH WAS NOT CONFIRMED, AND POSSIBLE BILLOWING WITH A TYPE 2 ENDOLEAK. THE PATIENT WAS ASYMPTOMATIC. DURING RE-INTERVENTION, THE PATIENT WAS RELINED BY IMPLANTING AN AFX2 BIFURCATED STENT GRAFT AND ONE ADDITIONAL VELA SUPRARENAL ON (B)(6) 2017 BY PHYSICIAN (B)(6).

Additional Manufacturer Narrative · 1

AT THE COMPLETION OF THE CLINICAL EVALUATION AND BASED ON THE INFORMATION RECEIVED, THERE WAS SUBSTANTIAL EVIDENCE TO SUPPORT THE FOLLOWING REPORTED EVENTS: ENDOLEAKS 1A AND 2, AND ENDOVASCULAR RELINING. THERE WAS SUBSTANTIAL EVIDENCE TO REFUTE THE FOLLOWING REPORTED EVENTS: ENDOLEAK 3A, RATHER THERE WAS AN ENDOLEAK 3B NOTED ONE MONTH POST-IMPLANT (LEFT LATERAL DISTAL NEAR BIFURCATION). ADDITIONAL FINDINGS INCLUDE SAC GROWTH (8MM/27M) AT 27 MONTHS POST-IMPLANT. THE MOST LIKELY CAUSE OF THE PROXIMAL LOSS OF SEAL WAS THE HOSTILE AORTIC NECK ANATOMY AND THE PRESENCE OF A PATENT, LOW ACCESSORY RENAL ARTERY. THE MOST LIKELY CAUSE OF THE COMPROMISED STENT GRAFT INTEGRITY (BREACHED) OF THE MAIN BODY STENT WAS THE USE OF STRATA MATERIAL. PROCEDURE-RELATED HARMS INCLUDED A TYPE 2 ENDOLEAK. THE FINAL PATIENT DISPOSITION COULD NOT BE DETERMINED DUE TO THE LACK OF MEDICAL INFORMATION SURROUNDING THE IMPLANT AND REPAIR EVENTS. THE MANUFACTURING LOT REVIEW CONFIRMED ALL DEVICES MET SPECIFICATIONS PRIOR TO RELEASE. ENDOLOGIX CONTINUES TO INVESTIGATE THIS EVENT AND SIMILAR EVENTS TO ENSURE THE HIGHEST QUALITY AND PATIENT SAFETY. REFERENCE MANUFACTURER REPORT NUMBER 2031527-2018-00192 FOR FOLLOW-UP REPORT 001 TO AFX BIFURCATED STENT GRAFT, LOT # 1251692-025. THIS REPORT IS TO ADDRESS THE TYPE 1A ENDOLEAK FOUND AT CLINICAL EVALUATION TO AFX VELA SUPRARENAL, LOT # 1210034-013. A ROOT CAUSE INVESTIGATION WAS CARRIED OUT FOR ALL AFX COMPLAINTS HAVING AN IDENTIFIED FAILURE MODE OF A TYPE 3B ENDOLEAK. ENDOLOGIX IMPLEMENTED THE FOLLOWING CORRECTIVE ACTIONS WITH THE INTENT OF REDUCING TYPE 3B ENDOLEAK EVENTS; 1. UPGRADED GRAFT MATERIAL (I.E. DURAPLY) AND 2. UPDATES TO THE IFU AND ADDITIONAL PHYSICIAN TRAINING. THE CHANGE TO DURAPLY GRAFT MATERIAL AND THE IFU CHANGES WERE PUT IN PLACE JULY 2014. THE TYPE 3B ENDOLEAK RATE FOR AFX MANUFACTURED AND IMPLANTED BEFORE THESE CORRECTIVE ACTIONS WERE PUT IN PLACE IS TRENDING AT (B)(4). SINCE THE CORRECTIVE ACTIONS WERE IMPLEMENTED, THE TYPE 3B ENDOLEAK EVENTS REPORTED FOR AFX DEVICES HAS BEEN REDUCED TO (B)(4).

Description of Event or Problem · 1

ENDOLOGIX BECAME AWARE OF A RE-INTERVENTION ON (B)(6) 2017 AS REPORTED BY PHYSICIAN (B)(6). AS THE DATE OF EVENT IS UNKNOWN, THE BEST ESTIMATE (B)(6) 2017 WAS USED. THE PATIENT WAS ORIGINALLY IMPLANTED WITH AN AFX BIFURCATED STENT GRAFT AND VELA SUPRARENAL ON (B)(6) 2015 BY THE REPORTING PHYSICIAN. ON AN UNKNOWN DATE, THE PHYSICIAN SUSPECTED A 3A ENDOLEAK, WHICH WAS NOT CONFIRMED, AND POSSIBLE BILLOWING WITH A TYPE 2 ENDOLEAK. THE PATIENT WAS ASYMPTOMATIC. DURING RE-INTERVENTION, THE PATIENT WAS RELINED BY IMPLANTING AN AFX2 BIFURCATED STENT GRAFT AND ONE ADDITIONAL VELA SUPRARENAL ON (B)(6) 2017 BY PHYSICIAN (B)(6).

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
394062 AFX VELA SUPRARENAL MIH ENDOLOGIX INC. A25-25/C95-O20 V 1210034-013 0081009013620

Patients

Seq Age Sex Outcome Treatment
1 76 YR Required Intervention AFX-BIFURCATED STENT GRAFT - LOT 1251692-025| AFX-BIFURCATED STENT GRAFT - LOT 1251692-025