FDA Adverse Event Malfunction Summary report: N

CONFIRM ANTI-PROGESTERONE RECEPTOR (PR) (1E2) RABBIT MONOCLONAL PRIMARY ANTIBODY

MDR report key: 25159406 · Received May 13, 2026

Report

Report Number
2028492-2026-01879
Event Type
Malfunction
Date Received
May 13, 2026
Date of Event
April 20, 2026
Report Date
May 13, 2026
Manufacturer
VENTANA MEDICAL SYSTEMS INC.
Product Code
MXZ
UDI-DI
04015630972180
PMA / PMN Number
K103818
Product Problem
Yes
Report Source
Manufacturer report
Reporter Location
BR
Reporter Occupation
OTHER HEALTH CARE PROFESSIONAL
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

THE SERIAL NUMBER OF THE ANALYZER IS (B)(6). THE INVESTIGATION IS ONGOING.

Description of Event or Problem · 0

THERE WAS AN ALLEGATION OF QUESTIONABLE CONFIRM ANTI-PROGESTERONE RECEPTOR (PR) (1E2) RABBIT MONOCLONAL PRIMARY ANTIBODY ASSAY RESULTS FOR PATIENT SAMPLES TESTED ON THE BENCHMARK ULTRA INSTRUMENT. IT WAS REPORTED THAT ABOUT 4 TO 5 CASES IN WHICH THEY OBTAINED AN ESTROGEN RECEPTOR (ER) NEGATIVE, PROGESTERONE RECEPTOR (PR) POSITIVE (WEAK INTENSITY, IN 10 TO 20% OF THE CELLS), AND HER2 NEGATIVE RESULT. THE ONCOLOGIST REQUESTED THAT THE TESTS BE REPEATED AT ANOTHER INSTITUTION, AS THEY CONSIDERED THE POSITIVE PROGESTERONE AND NEGATIVE ER RESULT UNUSUAL. THE NEW RESULTS WERE PR NEGATIVE.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
76077 CONFIRM ANTI-PROGESTERONE RECEPTOR (PR) (1E2) RABBIT MONOCLONAL PRIMARY ANTIBODY IMMUNOHISTOCHEMISTRY ASSAY,ANTIBODY,PROGESTERONE RECEPTOR MXZ VENTANA MEDICAL SYSTEMS INC. N00775 04015630972180

Patients

Seq Age Sex Outcome Treatment
1