FDA Adverse Event Injury Summary report: N

P150048

MDR report key: 23158653 · Received September 26, 2025

Report

Report Number
2015691-2025-07931
Event Type
Injury
Date Received
September 26, 2025
Date of Event
September 3, 2025
Report Date
November 11, 2025
Manufacturer
EDWARDS LIFESCIENCES
Product Code
LWR
PMA / PMN Number
P150048
Adverse Event
Yes
Report Source
Manufacturer report
Reporter Location
CA, US
Reporter Occupation
PHYSICIAN
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

H11: ADDITIONAL MANUFACTURER NARRATIVE: THE INVESTIGATION IS STILL IN PROGRESS; THEREFORE, A CONCLUSION HAS YET TO BE ESTABLISHED. A SUPPLEMENTAL REPORT WILL BE SUBMITTED ACCORDINGLY UPON INVESTIGATION COMPLETION. EDWARDS WILL CONTINUE TO REVIEW AND MONITOR ALL REPORTED EVENTS. TRENDS ARE MONITORED ON A MONTHLY BASIS AND IF ACTION IS REQUIRED, APPROPRIATE INVESTIGATION WILL BE PERFORMED.

Additional Manufacturer Narrative · 0

H11: ADDITIONAL MANUFACTURER NARRATIVE: UPDATED: B4, G3, G6, H2, H6. DEHISCENCE REFERS TO THE SEPARATION OF THE PROSTHETIC VALVE FROM THE SURROUNDING HEART TISSUE, TYPICALLY AT THE SEWING RING WHERE THE VALVE IS SUTURED TO THE ANNULUS. THIS SEPARATION CAN CAUSE BLOOD TO LEAK AROUND THE VALVE (PARAVALVULAR REGURGITATION), REDUCING ITS EFFECTIVENESS AND STRAINING THE HEART. THIS GENERALLY OCCURS DUE TO PATIENT-RELATED ANATOMICAL FACTORS, SUCH AS IRREGULAR ANATOMY, WHICH MAY LEAD TO INCREASED STRESS ON THE SURROUNDING TISSUE OVER TIME. THIS IS OFTEN AS A RESULT OF SUCCESSIVE DILATION OF CARDIAC STRUCTURES CAUSED BY PROGRESSIONS OF VALVULAR DISEASE. A DEVICE HISTORY RECORD (DHR) REVIEW WAS UNABLE TO BE PERFORMED AS NO S/N WAS PROVIDED. THERE IS NO EVIDENCE TO SUGGEST A MANUFACTURING DEFECT CAUSED OR CONTRIBUTED TO THE REPORTED EVENT. BASED ON THE INFORMATION AVAILABLE, THE MOST LIKELY ROOT CAUSE IS PATIENT FACTORS.

Additional Manufacturer Narrative · 0

H11: ADDITIONAL MANUFACTURER NARRATIVE: UPDATED: B4, B5, B7, G3, G6, H2, H6.

Description of Event or Problem · 0

IT WAS REPORTED THAT A PATIENT WITH A 29MM 11500A INSPIRIS VALVE UNDERWENT VALVE-IN-VALVE INTERVENTION AFTER AN UNKNOWN IMPLANT DURATION DUE TO DEHISCENCE THAT RESULTED BLOOD FLOW INTO PSEUDOANEURYSM. THE TAVR PROCEDURE WAS SUCCESSFULLY PERFORMED WITH A 29MM 9755RSL TRANSCATHETER VALVE. THERE WAS NO PATIENT INJURY.

Description of Event or Problem · 0

IT WAS REPORTED THAT A PATIENT WITH A 29MM 11500A INSPIRIS VALVE UNDERWENT VALVE-IN-VALVE INTERVENTION AFTER AN UNKNOWN IMPLANT DURATION DUE TO DEHISCENCE. THE TAVR PROCEDURE WAS SUCCESSFULLY PERFORMED WITH A 29MM 9755RSL TRANSCATHETER VALVE.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
2124822 P150048 HEART-VALVE, NON-ALLOGRAFT TISSUE LWR EDWARDS LIFESCIENCES 11500A29

Patients

Seq Age Sex Outcome Treatment
1 59 YR Male Life Threatening| H| R