FDA Adverse Event Malfunction Summary report: N

ALTIUS SYSTEM

MDR report key: 21734984 · Received March 31, 2025

Report

Report Number
3026283936-2025-00006
Event Type
Malfunction
Date Received
March 31, 2025
Date of Event
September 30, 2025
Report Date
November 12, 2025
Manufacturer
NEUROS MEDICAL INC.
Product Code
SAZ
PMA / PMN Number
P230020
Adverse Event
Yes
Product Problem
Yes
Report Source
Manufacturer report
Reporter Location
CA, US
Reporter Occupation
BIOMEDICAL ENGINEER
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

CUFF LEAD S/N (B)(6) - THE IS-1 CONNECTOR SHOWED AN OPEN CIRCUIT FOR BOTH PIN AND RING LEAD WIRES AND FAILED CONTINUITY TESTING. PIN AND RING LEAD WIRES ARE BROKEN AT THE END OF THE EPOXY BACKFILL STEM OF THE JOINT. IS-1 CONNECTOR WAS BENT AND WHEN TESTED IT SHOWED NO CONTINUITY DUE TO BROKEN PIN AND RING WIRES AT EPOXY. THE NERVE CUFF ELECTRODE (LEAD) INVOLVED IN THIS EVENT, WAS UTILIZED UNDER IDE G130203 (SUBJECT OF THE QUEST CLINICAL STUDY) AND IS NOT THE APPROVED ALTIUS SYSTEM NERVE CUFF ELECTRODE (P230020/08-26-2024). NEUROS IS SUBMITTING THIS REPORT IN COMPLIANCE WITH FDA MEDICAL DEVICE REPORTING REGULATIONS UNDER 21 CFR PART 803.

Additional Manufacturer Narrative · 0

ALTHOUGH THE PRODUCT WILL NOT BE RETURNED AT THIS TIME FOR INVESTIGATION, IMPEDANCE MEASUREMENTS, REPORTED PATIENT SYMPTOMS AND HISTORICAL DEVICE KNOWLEDGE SUGGEST THAT A MECHANICAL BREAK OF THE NERVE CUFF ELECTRODE (LEAD) IS THE MOST LIKELY CAUSE. THE NERVE CUFF ELECTRODE (LEAD) INVOLVED IN THIS EVENT, WAS UTILIZED UNDER IDE G130203 (SUBJECT OF THE QUEST CLINICAL STUDY) AND IS NOT THE APPROVED ALTIUS SYSTEM NERVE CUFF ELECTRODE (P230020/08-26-2024). NEUROS IS SUBMITTING THIS REPORT IN COMPLIANCE WITH FDA MEDICAL DEVICE REPORTING REGULATIONS UNDER 21 CFR PART 803.

Additional Manufacturer Narrative · 0

ALTHOUGH THE PRODUCT WILL NOT BE RETURNED AT THIS TIME FOR INVESTIGATION, IMPEDANCE MEASUREMENTS, REPORTED PATIENT SYMPTOMS AND HISTORICAL DEVICE KNOWLEDGE SUGGEST THAT A MECHANICAL BREAK OF THE NERVE CUFF ELECTRODE (LEAD) IS THE MOST LIKELY CAUSE. THE NERVE CUFF ELECTRODE (LEAD) INVOLVED IN THIS EVENT, WAS UTILIZED UNDER IDE (B)(4) (SUBJECT OF THE QUEST CLINICAL STUDY) AND IS NOT THE APPROVED ALTIUS SYSTEM NERVE CUFF ELECTRODE (P230020/08-26-2024). NEUROS IS SUBMITTING THIS REPORT IN COMPLIANCE WITH FDA MEDICAL DEVICE REPORTING REGULATIONS UNDER 21 CFR PART 803.

Description of Event or Problem · 0

INFORMATION WAS RECEIVED FROM A PATIENT WHO WAS IMPLANTED WITH AN IMPLANTABLE PULSE GENERATOR AND LEAD FOR PAIN MANAGEMENT CAUSED BY BELOW-KNEE AMPUTATION. IT WAS REPORTED THAT THEIR DEVICE WAS CAUSING A STRONG SHOCKING SENSATION WHEN RUNNING THERAPY SESSIONS AT HOME. THE PATIENT ALSO EXPERIENCED PAIN AND DISCOMFORT AS A RESULT OF THE SHOCK, EVEN REPORTING FALLING OUT OF A CHAIR DUE TO SUCH DISCOMFORT. THIS PATIENT WAS ENROLLED IN THE QUEST TRIAL, NOW COMPLETED, AND CAME INTO THE HEALTH CARE FACILITY AT THE YEAR-6 ANNUAL LONG-TERM FOLLOW-UP VISIT. THE SHOCKING SENSATION IS EXPERIENCED ONLY DURING THERAPY SESSIONS AND IS INTERMITTENT WITH NORMALLY EXPECTED THERAPY-INDUCED SENSATION. AS AN IMMEDIATE REMEDIAL MEASURE, THE THERAPY STRENGTH WAS SIGNIFICANTLY LOWERED FROM THE CURRENT SETTINGS TO MINIMIZE THE DISCOMFORT DURING THERAPY SESSIONS. FOLLOW-UP (B)(6) 2025 - ANOTHER COMPLAINT OF SHOCKING SENSATION WAS SUBMITTED BY THE SUBJECT THROUGH THE COMPANY WEBSITE. THE CLINICAL SITE LOST THE SURGEON AND HAS IDENTIFIED A NEW ONE. THIS EXPLANT WILL BE SCHEDULED AS SOON AS POSSIBLE. FOLLOW-UP (B)(6) 2025 CONFIRMED THE CLINICAL SITE PERFORMED AN EXPLANT OF THE ALTIUS SYSTEM. THE PROCEDURE WAS SUCCESSFUL WITH NO CLINICAL SEQUELA REPORTED. CUFF LED S/N (B)(6) - THE IS-1 CONNECTOR SHOWED AN OPEN CIRCUIT FOR BOTH PIN AND RING LEAD WIRES AND FAILED CONTINUITY TESTING. PIN AND RING LEAD WIRES ARE BROKEN AT THE END OF THE EPOXY BACKFILL STEM OF THE JOINT. IS-1 CONNECTOR WAS BENT AND WHEN TESTED IT SHOWED NO CONTINUITY DUE TO BROKEN PIN AND RING WIRES AT EPOXY.

Description of Event or Problem · 0

INFORMATION WAS RECEIVED FROM A PATIENT WHO WAS IMPLANTED WITH AN IMPLANTABLE PULSE GENERATOR AND LEAD FOR PAIN MANAGEMENT CAUSED BY BELOW-KNEE AMPUTATION. IT WAS REPORTED THAT THEIR DEVICE WAS CAUSING A STRONG SHOCKING SENSATION WHEN RUNNING THERAPY SESSIONS AT HOME. THE PATIENT ALSO EXPERIENCED PAIN AND DISCOMFORT AS A RESULT OF THE SHOCK, EVEN REPORTING FALLING OUT OF A CHAIR DUE TO SUCH DISCOMFORT. THIS PATIENT WAS ENROLLED IN THE QUEST TRIAL, NOW COMPLETED, AND CAME INTO THE HEALTH CARE FACILITY AT THE YEAR-6 ANNUAL LONG-TERM FOLLOW-UP VISIT. THE SHOCKING SENSATION IS EXPERIENCED ONLY DURING THERAPY SESSIONS AND IS INTERMITTENT WITH NORMALLY EXPECTED THERAPY-INDUCED SENSATION. AS AN IMMEDIATE REMEDIAL MEASURE, THE THERAPY STRENGTH WAS SIGNIFICANTLY LOWERED FROM THE CURRENT SETTINGS TO MINIMIZE THE DISCOMFORT DURING THERAPY SESSIONS.

Description of Event or Problem · 0

INFORMATION WAS RECEIVED FROM A PATIENT WHO WAS IMPLANTED WITH AN IMPLANTABLE PULSE GENERATOR AND LEAD FOR PAIN MANAGEMENT CAUSED BY BELOW-KNEE AMPUTATION. IT WAS REPORTED THAT THEIR DEVICE WAS CAUSING A STRONG SHOCKING SENSATION WHEN RUNNING THERAPY SESSIONS AT HOME. THE PATIENT ALSO EXPERIENCED PAIN AND DISCOMFORT AS A RESULT OF THE SHOCK, EVEN REPORTING FALLING OUT OF A CHAIR DUE TO SUCH DISCOMFORT. THIS PATIENT WAS ENROLLED IN THE QUEST TRIAL, NOW COMPLETED, AND CAME INTO THE HEALTH CARE FACILITY AT THE YEAR-6 ANNUAL LONG-TERM FOLLOW-UP VISIT. THE SHOCKING SENSATION IS EXPERIENCED ONLY DURING THERAPY SESSIONS AND IS INTERMITTENT WITH NORMALLY EXPECTED THERAPY-INDUCED SENSATION. AS AN IMMEDIATE REMEDIAL MEASURE, THE THERAPY STRENGTH WAS SIGNIFICANTLY LOWERED FROM THE CURRENT SETTINGS TO MINIMIZE THE DISCOMFORT DURING THERAPY SESSIONS. FOLLOW-UP (B)(6) 2025 - ANOTHER COMPLAINT OF SHOCKING SENSATION WAS SUBMITTED BY THE SUBJECT THROUGH THE COMPANY WEBSITE. THE CLINICAL SITE LOST THE SURGEON AND HAS IDENTIFIED A NEW ONE. THIS EXPLANT WILL BE SCHEDULED AS SOON AS POSSIBLE.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
1166254 ALTIUS SYSTEM NERVE CUFF ELECTRODE SAZ NEUROS MEDICAL INC. FG-602-002 20020402

Patients

Seq Age Sex Outcome Treatment
1 61 YR Male Other