FDA Adverse Event Death Summary report: N

WATCHMAN FLX? PRO

MDR report key: 20579908 · Received October 31, 2024

Report

Report Number
2124215-2024-67803
Event Type
Death
Date Received
October 31, 2024
Date of Event
October 24, 2024
Report Date
May 7, 2025
Manufacturer
BOSTON SCIENTIFIC CORPORATION
Product Code
NGV
UDI-DI
00191506004590
PMA / PMN Number
P130013
Adverse Event
Yes
Report Source
Manufacturer report
Reporter Location
KS, US
Reporter Occupation
PHYSICIAN
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

H6 PATIENT CODE ADDED: RENAL FAILURE. H6 IMPACT CODES ADDED: ADDITIONAL DEVICE REQUIRED, REHABILITATION, DEATH.

Additional Manufacturer Narrative · 0

B5: INFORMATION ADDED AND CORRECTED.

Additional Manufacturer Narrative · 0

B5: INFORMATION ADDED. H6 PATIENT CODES ADDED: FACIAL PARALYSIS, MUSCLE WEAKNESS/ATROPHY. H6 IMPACT CODE ADDED: MEDICATION REQUIRED, INTENSIVE CARE.

Additional Manufacturer Narrative · 0

B5: INFORMATION ADDED. H6 PATIENT CODE ADDED: CONVULSION/SEIZURE.

Description of Event or Problem · 0

THE PATIENT WAS PART OF A CLINICAL STUDY IT WAS REPORTED A STROKE OCCURRED. A LEFT ATRIAL APPENDAGE (LAA) CLOSURE PROCEDURE WAS PERFORMED AND A 24MM WATCHMAN FLX PRO CLOSURE DEVICE WAS IMPLANTED WITH A COMPLETE LAA SEAL AND DEPLOYED DEVICE DIAMETER OF 18.9 MM. THE PATIENT WAS DISCHARGED ON ASPIRIN AND WARFARIN. 167 DAYS POST INDEX PROCEDURE, THE PATIENT PRESENTED TO THE HOSPITAL FOR A T2 VERTEBRAL FRACTURE. AT THE TIME OF THE EVENT, THE PATIENT WAS ON ASPIRIN AND WARFARIN. BRAIN IMAGING AND COMPUTED TOMOGRAPHY (CT) WAS PERFORMED, ALONG WITH OTHER DIAGNOSTICS. THE PATIENT WAS ADMITTED TO THE HOSPITAL. 185 DAYS POST INDEX PROCEDURE, THE PATIENT UNDERWENT BRAIN IMAGING, CT IMAGING, MAGNETIC RESONANCE IMAGING (MRI), AND OTHER DIAGNOSTICS. THE PATIENT WAS DIAGNOSED WITH ISCHEMIC STROKE. THAT SAME DAY, THE EVENT WAS CONSIDERED RESOLVED WITH SEQUALAE. IT WAS FURTHER ADDED THAT THE PATIENT HAD PRESENTED TO THE HOSPITAL 185 DAYS POST INDEX PROCEDURE POST HEMODIALYSIS (HD) DUE TO END STAGE RENAL DISEASE (ESRD), AND AFTER THE COMPLETION OF THAT HD THE PATIENT HAD NEW RIGHT SIDED FACIAL DROOP AND RIGHT SIDED ARM AND LEG WEAKNESS. THE EMERGENCY DEPARTMENT ADMINISTERED OMNIPAQUE INTRAVENOUSLY. THE INITIAL NATIONAL INSITUTE OF HEALTH STROKE SCALE SCORE WAS 4. TENECTEPLASE (TNK) WAS ADMINISTERED IN RESPONSE TO THE ISCHEMIC STROKE AND THE PATIENT WAS TAKEN TO THE NEURO INTENSIVE CARE UNIT (ICU) FOR MONITORING. DUAL ANTIPLATELET (DAPT) MEDICATION WAS HELD AND INSTRUCTED TO RESUME AT A LATER DATE. TRANSESOPHAGEAL ECHOCARDIOGRAM (TEE) IMAGING PERFORMED REVEALED COMPLETE LAA SEAL, AND NO THROMBUS IN THE LEFT ATRIUM OR ON THE ATRIAL FACING SURFACE OF THE CLOSURE DEVICE. THE PATIENT WAS DISCHARGED 190 DAYS POST INDEX PROCEDURE. IT WAS FURTHER REPORTED THAT ON (B)(6) 2024, 207 DAYS POST INDEX PROCEDURE, THE PATIENT PRESENTED WITH COMPLAINTS OF LEFT SIDED WEAKNESS AND WAS DIAGNOSED WITH ACUTE ISCHEMIC RIGHT ANTERIOR CEREBRAL ARTERY STROKE VIA A MAGNETIC RESONANCE IMAGING (MRI) SCAN WHICH REVEALED A MODERATE SIZED ACUTE/RECENT RIGHT MEDIAL FRONTAL INFARCT. AT THE TIME OF THE EVENT, THE PATIENT WAS ON ASPIRIN. THE PATIENT WAS ADMITTED TO THE INTENSIVE CARE UNIT AND WAS TREATED WITH NON-ANTIPLATELET/NON-ANTICOAGULANT MEDICATIONS AND A PACEMAKER WAS IMPLANTED. THE PATIENT WAS DISCHARGED ON(B)(6) 2024, TO A SKILLED NURSING/REHABILITATION FACILITY. THE PATIENT DIED THE FOLLOWING DAY ON (B)(6)2024. THE CAUSE OF DEATH WAS LISTED AS WORSENING END STAGE RENAL DISEASE.

Description of Event or Problem · 0

THE PATIENT WAS PART OF A CLINICAL STUDY. IT WAS REPORTED A STROKE OCCURRED. A LEFT ATRIAL APPENDAGE (LAA) CLOSURE PROCEDURE WAS PERFORMED AND A 24MM WATCHMAN FLX PRO CLOSURE DEVICE WAS IMPLANTED WITH A COMPLETE LAA SEAL AND DEPLOYED DEVICE DIAMETER OF 18.9 MM. THE PATIENT WAS DISCHARGED ON ASPIRIN AND WARFARIN. 167 DAYS POST INDEX PROCEDURE, THE PATIENT PRESENTED TO THE HOSPITAL FOR A T2 VERTEBRAL FRACTURE. AT THE TIME OF THE EVENT, THE PATIENT WAS ON ASPIRIN AND WARFARIN. BRAIN IMAGING AND COMPUTED TOMOGRAPHY (CT) WAS PERFORMED, ALONG WITH OTHER DIAGNOSTICS. THE PATIENT WAS ADMITTED TO THE HOSPITAL. 185 DAYS POST INDEX PROCEDURE, THE PATIENT UNDERWENT BRAIN IMAGING, CT IMAGING, MAGNETIC RESONANCE IMAGING (MRI), AND OTHER DIAGNOSTICS. THE PATIENT WAS DIAGNOSED WITH ISCHEMIC STROKE. THAT SAME DAY, THE EVENT WAS CONSIDERED RESOLVED WITH SEQUALAE. IT WAS FURTHER ADDED THAT THE PATIENT HAD PRESENTED TO THE HOSPITAL 185 DAYS POST INDEX PROCEDURE POST HEMODIALYSIS (HD) DUE TO END STAGE RENAL DISEASE (ESRD), AND AFTER THE COMPLETION OF THAT HD THE PATIENT HAD NEW RIGHT SIDED FACIAL DROOP AND RIGHT SIDED ARM AND LEG WEAKNESS. THE EMERGENCY DEPARTMENT ADMINISTERED OMNIPAQUE INTRAVENOUSLY. THE INITIAL NATIONAL INSTITUTE OF HEALTH STROKE SCALE SCORE WAS 4. TENECTEPLASE (TNK) WAS ADMINISTERED IN RESPONSE TO THE ISCHEMIC STROKE AND THE PATIENT WAS TAKEN TO THE NEURO INTENSIVE CARE UNIT (ICU) FOR MONITORING. DUAL ANTIPLATELET (DAPT) MEDICATION WAS HELD AND INSTRUCTED TO RESUME AT A LATER DATE. TRANSESOPHAGEAL ECHOCARDIOGRAM (TEE) IMAGING PERFORMED REVEALED COMPLETE LAA SEAL, AND NO THROMBUS IN THE LEFT ATRIUM OR ON THE ATRIAL FACING SURFACE OF THE CLOSURE DEVICE. THE PATIENT WAS DISCHARGED 190 DAYS POST INDEX PROCEDURE. IT WAS FURTHER REPORTED THAT ON (B)(6)2024, 207 DAYS POST INDEX PROCEDURE, THE PATIENT PRESENTED WITH COMPLAINTS OF LEFT SIDED WEAKNESS AND WAS DIAGNOSED WITH ACUTE ISCHEMIC RIGHT ANTERIOR CEREBRAL ARTERY STROKE VIA A MAGNETIC RESONANCE IMAGING (MRI) SCAN WHICH REVEALED A MODERATE SIZED ACUTE/RECENT RIGHT MEDIAL FRONTAL INFARCT. AT THE TIME OF THE EVENT, THE PATIENT WAS ON ASPIRIN. THE PATIENT WAS ADMITTED TO THE INTENSIVE CARE UNIT AND WAS TREATED WITH NON-ANTIPLATELET/NON-ANTICOAGULANT MEDICATIONS AND A PACEMAKER WAS IMPLANTED. THE PATIENT WAS DISCHARGED ON (B)(6) 2024, TO A SKILLED NURSING/REHABILITATION FACILITY. THE PATIENT DIED THE FOLLOWING DAY ON (B)(6) 2024. THE CAUSE OF DEATH WAS LISTED AS WORSENING END STAGE RENAL DISEASE. IT WAS FURTHER CORRECTED THAT THE PATIENT DIED ON (B)(6) 2024. IT WAS FURTHER ADDED THAT THE PATIENT HAD THE PACEMAKER IMPLANTED ON (B)(6) 2024, BUT THEN HAD THE PACEMAKER REMOVED FROM THE BODY ON (B)(6) 2024, AND THE PATIENT WAS CONSULTED WITH PALLIATIVE CARE THEN DISCHARGED TO THE SKILLED NURSING/REHABILITATION FACILITY.

Description of Event or Problem · 0

THE PATIENT WAS PART OF A CLINICAL STUDY. IT WAS REPORTED A STROKE OCCURRED. A LEFT ATRIAL APPENDAGE (LAA) CLOSURE PROCEDURE WAS PERFORMED AND A 24MM WATCHMAN FLX PRO CLOSURE DEVICE WAS IMPLANTED WITH A COMPLETE LAA SEAL AND DEPLOYED DEVICE DIAMETER OF 18.9 MM. THE PATIENT WAS DISCHARGED ON ASPIRIN AND WARFARIN. 167 DAYS POST INDEX PROCEDURE, THE PATIENT PRESENTED TO THE HOSPITAL FOR A T2 VERTEBRAL FRACTURE. AT THE TIME OF THE EVENT, THE PATIENT WAS ON ASPIRIN AND WARFARIN. BRAIN IMAGING AND COMPUTED TOMOGRAPHY (CT) WAS PERFORMED, ALONG WITH OTHER DIAGNOSTICS. THE PATIENT WAS ADMITTED TO THE HOSPITAL. 185 DAYS POST INDEX PROCEDURE, THE PATIENT UNDERWENT BRAIN IMAGING, CT IMAGING, MAGNETIC RESONANCE IMAGING (MRI), AND OTHER DIAGNOSTICS. THE PATIENT WAS DIAGNOSED WITH ISCHEMIC STROKE. THAT SAME DAY, THE EVENT WAS CONSIDERED RESOLVED WITH SEQUALAE. IT WAS FURTHER ADDED THAT THE PATIENT HAD PRESENTED TO THE HOSPITAL 185 DAYS POST INDEX PROCEDURE POST HEMODIALYSIS (HD) DUE TO END STAGE RENAL DISEASE (ESRD), AND AFTER THE COMPLETION OF THAT HD THE PATIENT HAD NEW RIGHT SIDED FACIAL DROOP AND RIGHT SIDED ARM AND LEG WEAKNESS. THE EMERGENCY DEPARTMENT ADMINISTERED OMNIPAQUE INTRAVENOUSLY. THE INITIAL NATIONAL INSITUTE OF HEALTH STROKE SCALE SCORE WAS 4. TENECTEPLASE (TNK) WAS ADMINISTERED IN RESPONSE TO THE ISCHEMIC STROKE AND THE PATIENT WAS TAKEN TO THE NEURO INTENSIVE CARE UNIT (ICU) FOR MONITORING. DUAL ANTIPLATELET (DAPT) MEDICATION WAS HELD AND INSTRUCTED TO RESUME AT A LATER DATE. TRANSESOPHAGEAL ECHOCARDIOGRAM (TEE) IMAGING PERFORMED REVEALED COMPLETE LAA SEAL, AND NO THROMBUS IN THE LEFT ATRIUM OR ON THE ATRIAL FACING SURFACE OF THE CLOSURE DEVICE. THE PATIENT WAS DISCHARGED 190 DAYS POST INDEX PROCEDURE.

Description of Event or Problem · 0

THE PATIENT WAS PART OF A CLINICAL STUDY. IT WAS REPORTED A STROKE OCCURRED. A LEFT ATRIAL APPENDAGE (LAA) CLOSURE PROCEDURE WAS PERFORMED AND A 24MM WATCHMAN FLX PRO CLOSURE DEVICE WAS IMPLANTED WITH A COMPLETE LAA SEAL AND DEPLOYED DEVICE DIAMETER OF 18.9 MM. THE PATIENT WAS DISCHARGED ON ASPIRIN AND WARFARIN. 167 DAYS POST INDEX PROCEDURE, THE PATIENT PRESENTED TO THE HOSPITAL FOR A T2 VERTEBRAL FRACTURE. AT THE TIME OF THE EVENT, THE PATIENT WAS ON ASPIRIN AND WARFARIN. BRAIN IMAGING AND COMPUTED TOMOGRAPHY (CT) WAS PERFORMED, ALONG WITH OTHER DIAGNOSTICS. THE PATIENT WAS ADMITTED TO THE HOSPITAL. 185 DAYS POST INDEX PROCEDURE, THE PATIENT UNDERWENT BRAIN IMAGING, CT IMAGING, MAGNETIC RESONANCE IMAGING (MRI), AND OTHER DIAGNOSTICS. THE PATIENT WAS DIAGNOSED WITH ISCHEMIC STROKE. THAT SAME DAY, THE EVENT WAS CONSIDERED RESOLVED WITH SEQUALAE. IT WAS FURTHER ADDED THAT THE PATIENT HAD PRESENTED TO THE HOSPITAL 185 DAYS POST INDEX PROCEDURE POST HEMODIALYSIS (HD) DUE TO END STAGE RENAL DISEASE (ESRD), AND AFTER THE COMPLETION OF THAT HD THE PATIENT HAD NEW RIGHT SIDED FACIAL DROOP AND RIGHT SIDED ARM AND LEG WEAKNESS. THE EMERGENCY DEPARTMENT ADMINISTERED OMNIPAQUE INTRAVENOUSLY. THE INITIAL NATIONAL INSITUTE OF HEALTH STROKE SCALE SCORE WAS 4. TENECTEPLASE (TNK) WAS ADMINISTERED IN RESPONSE TO THE ISCHEMIC STROKE AND THE PATIENT WAS TAKEN TO THE NEURO INTENSIVE CARE UNIT (ICU) FOR MONITORING. DUAL ANTIPLATELET (DAPT) MEDICATION WAS HELD AND INSTRUCTED TO RESUME AT A LATER DATE. TRANSESOPHAGEAL ECHOCARDIOGRAM (TEE) IMAGING PERFORMED REVEALED COMPLETE LAA SEAL, AND NO THROMBUS IN THE LEFT ATRIUM OR ON THE ATRIAL FACING SURFACE OF THE CLOSURE DEVICE. THE PATIENT WAS DISCHARGED 190 DAYS POST INDEX PROCEDURE. IT WAS FURTHER REPORTED THAT ON (B)(6) 2024, 207 DAYS POST INDEX PROCEDURE, THE PATIENT PRESENTED WITH COMPLAINTS OF LEFT SIDED WEAKNESS AND WAS DIAGNOSED WITH ACUTE ISCHEMIC RIGHT ANTERIOR CEREBRAL ARTERY STROKE VIA A MAGNETIC RESONANCE IMAGING (MRI) SCAN WHICH REVEALED A MODERATE SIZED ACUTE/RECENT RIGHT MEDIAL FRONTAL INFARCT. AT THE TIME OF THE EVENT, THE PATIENT WAS ON ASPIRIN. THE PATIENT WAS ADMITTED TO THE INTENSIVE CARE UNIT AND WAS TREATED WITH NON-ANTIPLATELET/NON-ANTICOAGULANT MEDICATIONS AND A PACEMAKER WAS IMPLANTED. THE PATIENT WAS DISCHARGED ON (B)(6) 2024, TO A SKILLED NURSING/REHABILITATION FACILITY. THE PATIENT DIED THE FOLLOWING DAY ON (B)(6) 2024. THE CAUSE OF DEATH WAS LISTED AS WORSENING END STAGE RENAL DISEASE. IT WAS FURTHER CORRECTED THAT THE PATIENT DIED ON (B)(6) 2024. IT WAS FURTHER ADDED THAT THE PATIENT HAD THE PACEMAKER IMPLANTED ON (B)(6) 2024, BUT THEN HAD THE PACEMAKER REMOVED FROM THE BODY ON (B)(6) 2024, AND THE PATIENT WAS CONSULTED WITH PALLIATIVE CARE THEN DISCHARGED TO THE SKILLED NURSING/REHABILITATION FACILITY. IT WAS FURTHER REPORTED AND CORRECTED THAT THE ONSET DATE OF THE LEFT SIDED WEAKNESS WAS (B)(6) 2024, NOT (B)(6) 2024, AND THAT THE PATIENT HAD ADDITIONALLY ALSO EXPERIENCED A SEIZURE. THE EMERGENCY DEPARTMENT REVIEW OF SYSTEMS REVEALED POSITIVE FOR SEIZURES. THE PATIENT WAS NOT A CANDIDATE FOR TREATING WITH TENECTEPLASE (TNK) (AS THE PATIENT WAS RECENTLY ADMINISTERED TNK FOR THE PREVIOUS ISCHEMIC STROKE EXPERIENCED 185 DAYS POST INDEX PROCEDURE), SO WAS TREATED WITH IOHEXOL MEDICATION, INTRAVENOUS 0.9PERCENT NACL INJECTION, VASOPRESSORS AND MIDRODRINE. THE INITIAL NATIONAL INSITUTE OF HEALTH STROKE SCALE SCORE WAS 9.

Description of Event or Problem · 0

(B)(4) STUDY. IT WAS REPORTED A STROKE OCCURRED. A LEFT ATRIAL APPENDAGE (LAA) CLOSURE PROCEDURE WAS PERFORMED AND A 24MM WATCHMAN FLX PRO CLOSURE DEVICE WAS IMPLANTED WITH A COMPLETE LAA SEAL AND DEPLOYED DEVICE DIAMETER OF 18.9 MM. THE PATIENT WAS DISCHARGED ON ASPIRIN AND WARFARIN. 167 DAYS POST INDEX PROCEDURE, THE PATIENT PRESENTED TO THE HOSPITAL FOR A T2 VERTEBRAL FRACTURE. AT THE TIME OF THE EVENT, THE PATIENT WAS ON ASPIRIN AND WARFARIN. BRAIN IMAGING AND COMPUTED TOMOGRAPHY (CT) WAS PERFORMED, ALONG WITH OTHER DIAGNOSTICS. THE PATIENT WAS ADMITTED TO THE HOSPITAL. 185 DAYS POST INDEX PROCEDURE, THE PATIENT UNDERWENT BRAIN IMAGING, CT IMAGING, MAGNETIC RESONANCE IMAGING (MRI), AND OTHER DIAGNOSTICS. THE PATIENT WAS DIAGNOSED WITH ISCHEMIC STROKE. THAT SAME DAY, THE EVENT WAS CONSIDERED RESOLVED WITH SEQUALAE.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
1983811 WATCHMAN FLX? PRO SYSTEM, APPENDAGE CLOSURE, LEFT ATRIAL NGV BOSTON SCIENTIFIC CORPORATION M635WU60240 0032981020 00191506004590

Patients

Seq Age Sex Outcome Treatment
1 79 YR Male Other| S| D| H