FDA Adverse Event Injury Summary report: N

EDWARDS PERICARDIAL AORTIC BIOPROSTHESIS

MDR report key: 20325062 · Received September 27, 2024

Report

Report Number
2015691-2024-07461
Event Type
Injury
Date Received
September 27, 2024
Date of Event
September 3, 2024
Report Date
November 21, 2024
Manufacturer
EDWARDS LIFESCIENCES
Product Code
LWR
PMA / PMN Number
NA
Adverse Event
Yes
Report Source
Manufacturer report
Reporter Location
PA, US
Reporter Occupation
PHYSICIAN
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

H11. ADDITIONAL NARRATIVE. UPDATED D4. A DEVICE HISTORY RECORD (DHR) REVIEW IS NOT REQUIRED BECAUSE THERE IS NO ALLEGATION OF A MALFUNCTION WHICH COULD BE RELATED TO A MANUFACTURING NON-CONFORMANCE AND/OR ONE WAS NOT SUSPECTED OR CONFIRMED THROUGH INVESTIGATION; NO LABELING NON-CONFORMANCE/DEFICIENCY; NO DEVICE-RELATED INFECTION; AND NO EVIDENCE OF A PRODUCT FAILURE WITH REGARD TO DESIGN, RELIABILITY, OR USE ERROR.

Additional Manufacturer Narrative · 0

H11. ADDITIONAL NARRATIVE. UPDATED H3 AND H6. H3: PRODUCT EVALUATION. CUSTOMER REPORT OF PANNUS WAS CONFIRMED. STENOSIS, WORSENING GRADIENT, AND REDUCED EXCURSION WERE UNABLE TO BE CONFIRMED THROUGH VISUAL OBSERVATIONS. X-RAY DEMONSTRATED COMMISSURES 1 AND 3 BENT INWARD. MINIMAL HOST TISSUE OVERGROWTH ENCROACHED ONTO THE TISSUE AND INTO THE ORIFICE AT THE GREATEST DISTANCE OF APPROXIMATELY 2MM ON LEAFLET 2 ON THE INFLOW ASPECT AND 1MM ON LEAFLET 2 ON THE OUTFLOW ASPECT. HOST TISSUE ON THE STENT CIRCUMFERENCE WAS MINIMAL AT THE INFLOW ASPECT. SEWING RING HAD A CUT AROUND THE VALVE.

Additional Manufacturer Narrative · 0

H11. ADDITIONAL NARRATIVE THIS DEVICE IS NOT SOLD OR MARKETED IN THE UNITED STATES; HOWEVER, IT IS SIMILAR TO THE BRAND EDWARDS INSPIRIS RESILIA AORTIC VALVE, MODEL# 11500A, PMA# P150048. SURGICAL/PERCUTANEOUS INTERVENTION IS INDICATED OR PERFORMED, OR HARM OCCURRED DUE TO THE DEVICE, OR THERE IS A DEVICE MALFUNCTION THAT COULD CAUSE OR CONTRIBUTE TO A SERIOUS INJURY. THIS EVENT IS CONSIDERED A SERIOUS INJURY. THE DEVICE WAS RETURNED AND PRODUCT EVALUATION IS ONGOING. THE INVESTIGATION IS STILL IN PROGRESS; THEREFORE, A CONCLUSION HAS YET TO BE ESTABLISHED. A SUPPLEMENTAL REPORT WILL BE SUBMITTED ACCORDINGLY UPON INVESTIGATION COMPLETION.

Additional Manufacturer Narrative · 0

H11. ADDITIONAL NARRATIVE. UPDATED H6. THE MOST LIKELY ROOT CAUSE IS PATIENT FACTORS.

Description of Event or Problem · 0

IT WAS REPORTED VIA CLINICAL TRIAL THAT A 11000A 21MM PERICARDIAL AORTIC VALVE WAS EXPLANTED AFTER AN IMPLANT DURATION OF 9 YEARS, 2 MONTHS VIA A ROSS PROCEDURE DUE TO SEVERE STENOSIS WITH PANNUS AND WORSENING GRADIENTS, SEVERELY REDUCED EXCURSION. PER MEDICAL RECORDS, THE PATIENT PRESENTED WITH NYHA CLASS I, AND UNDERWENT ROSS PROCEDURE WITH CORONARY ARTERY REIMPLANTATION, ASCENDING AORTIC REPLACEMENT, AND PULMONIC ROOT REPLACEMENT. INTRAOPERATIVELY, SURGEON NOTED THAT THERE WAS NO CALCIFICATION ON THE 11000A VALVE BUT RATHER WHITE SCAR-LIKE PANNUS CAUSING OBSTRUCTION THAT EXTENDED ONTO THE UNDERSIDE OF THE LEAFLETS INTERFERING WITH THE VALVE FUNCTION. PANNUS WAS DEBRIDED AND SUBAORTIC RING OF PANNUS WAS EXCISED. THE LEAFLETS OF THE EXPLANTED VALVE WERE SOFT AND MOVED NORMALLY FOR OPENING AND CLOSING AFTER THE PANNUS WAS REMOVED. THE PATIENT WAS TRANSPORTED WHILE INTUBATED TO ICU IN CRITICAL CONDITION. ON POD#7 PATIENT RECEIVED A PPM FOR CHB. THE PATIENT WAS DISCHARGED HOME IN GOOD CONDITION ON POD # 8. PER PATHOLOGY, EXPLANTED VALVE NOTED TO BE TAN-YELLOW, SEMI-CIRCULAR, HARD, BIOMEDICAL DEVICE GROSSLY CONSISTED OF MESH-LIKE WITH RIMS CONTAINING 3 LEAFLETS THAT OPEN EASILY.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
1709375 EDWARDS PERICARDIAL AORTIC BIOPROSTHESIS HEART-VALVE, NON-ALLOGRAFT TISSUE LWR EDWARDS LIFESCIENCES 11000A21MM

Patients

Seq Age Sex Outcome Treatment
1 32 YR Female Required Intervention| H| L