FDA Adverse Event Malfunction Summary report: N

BD BACTEC¿ MGIT¿ 960 PZA KIT

MDR report key: 20267582 · Received September 20, 2024

Report

Report Number
1119779-2024-00681
Event Type
Malfunction
Date Received
September 20, 2024
Date of Event
December 8, 2023
Report Date
March 10, 2025
Manufacturer
BECTON DICKINSON & CO. (SPARKS)
Product Code
MJA
UDI-DI
00382902451280
PMA / PMN Number
K021582
Adverse Event
Yes
Product Problem
Yes
Report Source
Manufacturer report
Reporter Location
IN, US
Reporter Occupation
OTHER HEALTH CARE PROFESSIONAL
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

D.4. MEDICAL DEVICE EXPIRATION DATE: UNKNOWN. H.4. DEVICE MANUFACTURE DATE: UNKNOWN. A DEVICE EVALUATION IS ANTICIPATED BUT HAS NOT YET BEGUN. UPON COMPLETION OF THE INVESTIGATION, A SUPPLEMENTAL REPORT WILL BE FILED.

Additional Manufacturer Narrative · 0

INVESTIGATION SUMMARY: BACTEC MGIT 960 PZA IS MANUFACTURED BY REHYDRATING COMPONENTS IN USP PURIFIED WATER AND MIXED INTO A HOMOGENOUS SOLUTION. THE SOLUTION IS THEN STERILE FILTERED, DISPENSED INTO VIALS AND STOPPERED. THE VIALS ARE LYOPHILIZED, AND CRIMP CAPS ARE APPLIED PER STANDARD OPERATING PROCEDURES (SOP). BACTEC MGIT 960 PZA SUPPLEMENT IS MANUFACTURED BY REHYDRATING THE MEDIA COMPONENTS WITH USP PURIFIED WATER AND MIXED UNTIL A HOMOGENEOUS SOLUTION IS OBTAINED. THE SOLUTION IS THEN STERILE FILTERED AND DISPENSED INTO VIALS; STOPPERS ARE MANUALLY PLACED IN THE VIAL OPENING; SEPTUM CAPS ARE MANUALLY PLACED ON TOP OF THE STOPPER AND THEN MECHANICALLY CRIMPED PER SOP. TWO BACTEC MGIT 960 PZA VIALS ARE THEN MANUALLY PACKAGED WITH SIX BACTEC MGIT 960 PZA SUPPLEMENT VIALS TO COMPLETE A BACTEC MGIT 960 PZA KIT (MATERIAL: 245128). THE BATCH HISTORY RECORD FOR BATCH: 33233971 AND ITS COMPONENTS WAS SATISFACTORY. RETENTION SAMPLES WERE TESTED PER THE STANDARD PERFORMANCE PROCEDURE WHICH IS ALSO DESCRIBED IN THE IFU (INSTRUCTIONS FOR USE, AVAILABLE ON BD.COM/E-LABELING) OR RESERVED FOR FURTHER INVESTIGATIONAL TESTING INTO THIS ISSUE. NO RETURN SAMPLES OR PHOTOS WERE RECEIVED FOR INVESTIGATION. THIS COMPLAINT IS CONFIRMED. TREND IN PERFORMANCE COMPLAINTS IDENTIFIED FOR (B)(4) MGIT PZA KIT. BD HAS INITIATED A CAPA (CORRECTIVE AND PREVENTATIVE ACTION) TO FORMALLY INVESTIGATE THE PERFORMANCE ISSUE. FOR IMPACTED BATCHES THAT WERE RELEASED, A FIELD ACTION HAS BEEN EXECUTED. BD WILL CONTINUE TO TREND COMPLAINTS FOR PERFORMANCE.

Additional Manufacturer Narrative · 0

THE FOLLOWING FIELDS HAVE BEEN UPDATED WITH ADDITIONAL INFORMATION: D4. MEDICAL DEVICE LOT #: FROM UNKNOWN TO 3233971. D4. MEDICAL DEVICE EXPIRATION DATE: FROM UNKNOWN TO 22-NOV-2024. D4. UNIQUE IDENTIFIER (UDI) #: (B)(4). H4. DEVICE MANUFACTURE DATE: FROM UNKNOWN TO 21-AUG-2023.

Description of Event or Problem · 0

IT WAS REPORTED WHEN USING THE BD BACTEC¿ MGIT¿ 960 PZA KIT, A FALSE PZA RESISTANT RESULT WAS OBTAINED FOR ONE (1) PATIENT SAMPLE. CONFIRMATORY PNCA GENE SEQUENCING WAS PERFORMED AND NO MUTATIONS WERE DETECTED INDICATING THE PZA RESULT WAS SUSCEPTIBLE. THE PATIENT'S TREATMENT WAS CHANGED BASED ON THE ERRONEOUS PZA RESULT FROM PZA TO MOXIFLOXACIN ANTIBIOTIC. THERE WERE NO FURTHER HEALTH IMPACT OR CONSEQUENCES REPORTED.

Description of Event or Problem · 0

IT WAS REPORTED WHEN USING THE BD BACTEC¿ MGIT¿ 960 PZA KIT, A FALSE PZA RESISTANT RESULT WAS OBTAINED FOR ONE (1) PATIENT SAMPLE. CONFIRMATORY PNCA GENE SEQUENCING WAS PERFORMED AND NO MUTATIONS WERE DETECTED INDICATING THE PZA RESULT WAS SUSCEPTIBLE. THE PATIENT'S TREATMENT WAS CHANGED BASED ON THE ERRONEOUS PZA RESULT FROM PZA TO MOXIFLOXACIN ANTIBIOTIC. THERE WERE NO FURTHER HEALTH IMPACT OR CONSEQUENCES REPORTED.

Description of Event or Problem · 0

IT WAS REPORTED WHEN USING THE BD BACTEC¿ MGIT¿ 960 PZA KIT, A FALSE PZA RESISTANT RESULT WAS OBTAINED FOR ONE (1) PATIENT SAMPLE. CONFIRMATORY PNCA GENE SEQUENCING WAS PERFORMED AND NO MUTATIONS WERE DETECTED INDICATING THE PZA RESULT WAS SUSCEPTIBLE. THE PATIENT'S TREATMENT WAS CHANGED BASED ON THE ERRONEOUS PZA RESULT FROM PZA TO MOXIFLOXACIN ANTIBIOTIC. THERE WERE NO FURTHER HEALTH IMPACT OR CONSEQUENCES REPORTED.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
1354084 BD BACTEC¿ MGIT¿ 960 PZA KIT SUSCEPTIBILITY TEST POWDERS, ANTIMYCOBACTERIAL MJA BECTON DICKINSON & CO. (SPARKS) 3233971 00382902451280

Patients

Seq Age Sex Outcome Treatment
1 NA Unknown Other