FDA Adverse Event Injury Summary report: N

COBE SPECTRA

MDR report key: 20127827 · Received September 3, 2024

Report

Report Number
1722028-2024-00371
Event Type
Injury
Date Received
September 3, 2024
Date of Event
November 13, 2019
Report Date
September 3, 2024
Manufacturer
TERUMO BCT
Product Code
LKN
PMA / PMN Number
BK080035
Adverse Event
Yes
Report Source
Manufacturer report
Reporter Location
NC, US
Reporter Occupation
OTHER HEALTH CARE PROFESSIONAL
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

CATALOG NUMBER, LOT NUMBER, MANUFACTURE AND EXPIRY DATE ARE NOT AVAILABLE AT THIS TIME. INVESTIGATION IS IN PROCESS, A FOLLOW-UP REPORT WILL BE PROVIDED. CATES, N. C., OAKLEY, D. J., & ONWUEMENE, O. A. (2018). THERAPEUTIC WHITE BLOOD CELL AND PLATELET DEPLETIONS USING THE SPECTRA OPTIA SYSTEM CONTINUOUS MONONUCLEAR CELL PROTOCOL. JOURNAL OF CLINICAL APHERESIS, 33(5), 580¿585. HTTPS://DOI.ORG/10.1002/JCA.21644.

Additional Manufacturer Narrative · 0

THIS REPORT IS BEING FILED TO PROVIDE ADDITIONAL INFORMATION IN H.6 AND H.11. CATALOG NUMBER, LOT NUMBER, MANUFACTURE AND EXPIRY DATE ARE NOT AVAILABLE AT THIS TIME. FURTHER EVALUATION OF THIS EVENT HAS DETERMINED THAT THE DEVICE DID NOT CAUSE OR CONTRIBUTE TO A DEATH OR SERIOUS INJURY, NOR IS THERE A LIKELY POTENTIAL FOR DEATH OR SERIOUS INJURY ASSOCIATED WITH THIS EVENT BASED ON ADDITIONAL INVESTIGATIONAL INFORMATION. THIS JOURNAL WAS PUBLISHED IN 2019, THE CURRENT DEVICES IN FIELD HAVE PRODUCT AND SOFTWARE CHANGES THAT WERE NOT IN PLACE FOR DEVICES USED MORE THAN 5 YEARS AGO. NO FURTHER REPORTING WILL BE PROVIDED AS THIS DOES NOT REPRESENT A REPORTABLE EVENT. CATES, N. C., OAKLEY, D. J., & ONWUEMENE, O. A. (2018). THERAPEUTIC WHITE BLOOD CELL AND PLATELET DEPLETIONS USING THE SPECTRA OPTIA SYSTEM CONTINUOUS MONONUCLEAR CELL PROTOCOL. JOURNAL OF CLINICAL APHERESIS, 33(5), 580¿585. HTTPS://DOI.ORG/10.1002/JCA.21644.

Additional Manufacturer Narrative · 0

THIS REPORT IS BEING FILED TO PROVIDE A CORRECTION IN D.2B. CATALOG NUMBER, LOT NUMBER, MANUFACTURE AND EXPIRY DATE ARE NOT AVAILABLE AT THIS TIME. FURTHER EVALUATION OF THIS EVENT HAS DETERMINED THAT THE DEVICE DID NOT CAUSE OR CONTRIBUTE TO A DEATH OR SERIOUS INJURY, NOR IS THERE A LIKELY POTENTIAL FOR DEATH OR SERIOUS INJURY ASSOCIATED WITH THIS EVENT BASED ON ADDITIONAL INVESTIGATIONAL INFORMATION. THIS JOURNAL WAS PUBLISHED IN 2019, THE CURRENT DEVICES IN FIELD HAVE PRODUCT AND SOFTWARE CHANGES THAT WERE NOT IN PLACE FOR DEVICES USED MORE THAN 5 YEARS AGO. NO FURTHER REPORTING WILL BE PROVIDED AS THIS DOES NOT REPRESENT A REPORTABLE EVENT. CATES, N. C., OAKLEY, D. J., & ONWUEMENE, O. A. (2018). THERAPEUTIC WHITE BLOOD CELL AND PLATELET DEPLETIONS USING THE SPECTRA OPTIA SYSTEM CONTINUOUS MONONUCLEAR CELL PROTOCOL. JOURNAL OF CLINICAL APHERESIS, 33(5), 580¿585. HTTPS://DOI.ORG/10.1002/JCA.21644.

Description of Event or Problem · 0

PER JOURNAL ARTICLE "THERAPEUTIC WHITE BLOOD CELL AND PLATELET DEPLETIONS USING THE SPECTRA OPTIA SYSTEM CONTINUOUS MONONUCLEAR CELL PROTOCOL". BY NANCY C. CATES, , DARLENE J. OAKLEY, , OLUWATOYOSI A. ONWUEMENE, ABSTRACT THE SPECTRA OPTIA APHERESIS SYSTEM® HAS ONLY RECENTLY BEEN APPROVED BY THE FOOD AND DRUG ADMINISTRATION (FDA) FOR THERAPEUTIC WHITE BLOOD CELL (WBC) AND IS NOT YET APPROVED FOR PLATELET DEPLETIONS. PRIOR TO FDA-APPROVAL OF THE WBC DEPLETION PROTOCOL, WHEN OUR AVAILABLE COBE SPECTRA APHERESIS SYSTEMS WERE OUT OF SERVICE, WE SUCCESSFULLY PERFORMED WBC DEPLETION USING A MODIFIED SPECTRA OPTIA APHERESIS SYSTEM CONTINUOUS MONONUCLEAR CELL (CMNC) PROTOCOL. USING THIS MODIFIED SPECTRA OPTIA CMNC PROTOCOL, WE CREATED INSTITUTIONAL PROTOCOLS FOR WBC AND PLATELET DEPLETIONS. WE PERFORMED 10 WBC DEPLETIONS IN 9 PATIENTS AND 2 PLATELET DEPLETIONS IN 2 PATIENTS. WE COMPARED PRE- AND POST-PROCEDURE WBC, PLATELET COUNT, AND HEMOGLOBIN TO THE SAME DATA FROM PATIENTS PREVIOUSLY TREATED ON THE COBE SPECTRA AND FOUND NO DIFFERENCE IN % WBC AND PLATELET REDUCTION. WE ALSO FOUND NO SIGNIFICANT DIFFERENCE IN POST-PROCEDURAL HEMATOCRIT DECLINE. ADDITIONALLY, ADVERSE REACTIONS WERE NOT INCREASED. THEREFORE, WE CONCLUDE THAT THE SPECTRA OPTIA CMNC PROTOCOL CAN BE SUCCESSFULLY MODIFIED FOR EFFECTIVE WBC AND PLATELET DEPLETIONS WITHOUT INCREASE IN ADVERSE REACTIONS. SPECIFIC DETAILS, SUCH AS PATIENT INFORMATION AND OUTCOME, WERE NOT INCLUDED IN THE ARTICLE FOR THESE EVENTS, THEREFORE THIS REPORT IS BEING PROVIDED AS A SUMMARY OF THE EVENTS. IT IS UNKNOWN AT THIS TIME IF MEDICAL INTERVENTION WAS REQUIRED FOR THESE EVENTS THE COLLECTION SET IS NOT AVAILABLE FOR RETURN BECAUSE IT WAS DISCARDED BY THE CUSTOMER.

Description of Event or Problem · 0

PER JOURNAL ARTICLE "THERAPEUTIC WHITE BLOOD CELL AND PLATELET DEPLETIONS USING THE SPECTRA OPTIA SYSTEM CONTINUOUS MONONUCLEAR CELL PROTOCOL". BY NANCY C. CATES, , DARLENE J. OAKLEY, , OLUWATOYOSI A. ONWUEMENE, ABSTRACT THE SPECTRA OPTIA APHERESIS SYSTEM® HAS ONLY RECENTLY BEEN APPROVED BY THE FOOD AND DRUG ADMINISTRATION (FDA) FOR THERAPEUTIC WHITE BLOOD CELL (WBC) AND IS NOT YET APPROVED FOR PLATELET DEPLETIONS. PRIOR TO FDA-APPROVAL OF THE WBC DEPLETION PROTOCOL, WHEN OUR AVAILABLE COBE SPECTRA APHERESIS SYSTEMS WERE OUT OF SERVICE, WE SUCCESSFULLY PERFORMED WBC DEPLETION USING A MODIFIED SPECTRA OPTIA APHERESIS SYSTEM CONTINUOUS MONONUCLEAR CELL (CMNC) PROTOCOL. USING THIS MODIFIED SPECTRA OPTIA CMNC PROTOCOL, WE CREATED INSTITUTIONAL PROTOCOLS FOR WBC AND PLATELET DEPLETIONS. WE PERFORMED 10 WBC DEPLETIONS IN 9 PATIENTS AND 2 PLATELET DEPLETIONS IN 2 PATIENTS. WE COMPARED PRE- AND POST-PROCEDURE WBC, PLATELET COUNT, AND HEMOGLOBIN TO THE SAME DATA FROM PATIENTS PREVIOUSLY TREATED ON THE COBE SPECTRA AND FOUND NO DIFFERENCE IN % WBC AND PLATELET REDUCTION. WE ALSO FOUND NO SIGNIFICANT DIFFERENCE IN POST-PROCEDURAL HEMATOCRIT DECLINE. ADDITIONALLY, ADVERSE REACTIONS WERE NOT INCREASED. THEREFORE, WE CONCLUDE THAT THE SPECTRA OPTIA CMNC PROTOCOL CAN BE SUCCESSFULLY MODIFIED FOR EFFECTIVE WBC AND PLATELET DEPLETIONS WITHOUT INCREASE IN ADVERSE REACTIONS. SPECIFIC DETAILS, SUCH AS PATIENT INFORMATION AND OUTCOME, WERE NOT INCLUDED IN THE ARTICLE FOR THESE EVENTS, THEREFORE THIS REPORT IS BEING PROVIDED AS A SUMMARY OF THE EVENTS. IT IS UNKNOWN AT THIS TIME IF MEDICAL INTERVENTION WAS REQUIRED FOR THESE EVENTS THE COLLECTION SET IS NOT AVAILABLE FOR RETURN BECAUSE IT WAS DISCARDED BY THE CUSTOMER.

Description of Event or Problem · 0

PER JOURNAL ARTICLE "THERAPEUTIC WHITE BLOOD CELL AND PLATELET DEPLETIONS USING THE SPECTRA OPTIA SYSTEM CONTINUOUS MONONUCLEAR CELL PROTOCOL". BY NANCY C. CATES, , DARLENE J. OAKLEY, , OLUWATOYOSI A. ONWUEMENE, ABSTRACT THE SPECTRA OPTIA APHERESIS SYSTEM® HAS ONLY RECENTLY BEEN APPROVED BY THE FOOD AND DRUG ADMINISTRATION (FDA) FOR THERAPEUTIC WHITE BLOOD CELL (WBC) AND IS NOT YET APPROVED FOR PLATELET DEPLETIONS. PRIOR TO FDA-APPROVAL OF THE WBC DEPLETION PROTOCOL, WHEN OUR AVAILABLE COBE SPECTRA APHERESIS SYSTEMS WERE OUT OF SERVICE, WE SUCCESSFULLY PERFORMED WBC DEPLETION USING A MODIFIED SPECTRA OPTIA APHERESIS SYSTEM CONTINUOUS MONONUCLEAR CELL (CMNC) PROTOCOL. USING THIS MODIFIED SPECTRA OPTIA CMNC PROTOCOL, WE CREATED INSTITUTIONAL PROTOCOLS FOR WBC AND PLATELET DEPLETIONS. WE PERFORMED 10 WBC DEPLETIONS IN 9 PATIENTS AND 2 PLATELET DEPLETIONS IN 2 PATIENTS. WE COMPARED PRE- AND POST-PROCEDURE WBC, PLATELET COUNT, AND HEMOGLOBIN TO THE SAME DATA FROM PATIENTS PREVIOUSLY TREATED ON THE COBE SPECTRA AND FOUND NO DIFFERENCE IN % WBC AND PLATELET REDUCTION. WE ALSO FOUND NO SIGNIFICANT DIFFERENCE IN POST-PROCEDURAL HEMATOCRIT DECLINE. ADDITIONALLY, ADVERSE REACTIONS WERE NOT INCREASED. THEREFORE, WE CONCLUDE THAT THE SPECTRA OPTIA CMNC PROTOCOL CAN BE SUCCESSFULLY MODIFIED FOR EFFECTIVE WBC AND PLATELET DEPLETIONS WITHOUT INCREASE IN ADVERSE REACTIONS. SPECIFIC DETAILS, SUCH AS PATIENT INFORMATION AND OUTCOME, WERE NOT INCLUDED IN THE ARTICLE FOR THESE EVENTS, THEREFORE THIS REPORT IS BEING PROVIDED AS A SUMMARY OF THE EVENTS. IT IS UNKNOWN AT THIS TIME IF MEDICAL INTERVENTION WAS REQUIRED FOR THESE EVENTS THE COLLECTION SET IS NOT AVAILABLE FOR RETURN BECAUSE IT WAS DISCARDED BY THE CUSTOMER.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
1342177 COBE SPECTRA SEPARATOR, AUTOMATED, BLOOD CELL, DIAGNOSTIC LKN TERUMO BCT

Patients

Seq Age Sex Outcome Treatment
1 NA Unknown Other