FDA Adverse Event Injury Summary report: N

ICY® INTRAVASCULAR HEAT EXCHANGE CATHETER KIT CUSTOM LUER APPLAUSE (HEPARIN)

MDR report key: 20032887 · Received August 22, 2024

Report

Report Number
3010617000-2024-00634
Event Type
Injury
Date Received
August 22, 2024
Date of Event
July 28, 2024
Report Date
October 22, 2024
Manufacturer
ZOLL CIRCULATION, INC.
Product Code
NCX
UDI-DI
00849111075237
PMA / PMN Number
K101987
Adverse Event
Yes
Product Problem
Yes
Report Source
Manufacturer report
Reporter Location
MD, US
Reporter Occupation
OTHER HEALTH CARE PROFESSIONAL
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

THE REPORTED COMPLAINT OF A SUSPECTED LEAK IN THE CATHETER BALLOON WAS CONFIRMED DURING FUNCTIONAL TESTING OF THE RETURNED ICY CATHETER (LOT #193912). A BONDING LEAK WAS OBSERVED AT THE DISTAL END OF THE MEDIAL BALLOON DURING THE FUNCTIONAL PRESSURE LEAK TEST. THE PROBABLE ROOT CAUSE OF THE REPORTED COMPLAINT COULD BE A LATENT DEFECT IN THE BOND. A FUNCTIONAL LEAK TEST OF THE RETURNED CATHETER WAS PERFORMED. ALL INFUSION PORTS AND LUMENS WERE FLUSHED WITHOUT RESISTANCE. DURING THE FUNCTIONAL PRESSURE LEAK TEST, THE CATHETER WAS CONNECTED TO A PRESSURIZED INFLATION DEVICE, AND THE BALLOONS WERE FULLY INFLATED WHEN PRESSURIZED UP TO 100 PSI. UPON PRESSURIZING THE CATHETER, A BONDING LEAK WAS OBSERVED AT THE DISTAL END OF THE MEDIAL BALLOON, CONFIRMING THE REPORTED COMPLAINT. IT IS UNLIKELY THAT THE DEFECTIVE CATHETER WAS SHIPPED. DURING MANUFACTURING, ALL CATHETERS ARE 100% INSPECTED FOR LEAKS BY SUBJECTING THEM TO PRESSURE TESTING. ONLY UNITS THAT PASSED ARE MOVED TO THE NEXT PROCESS. HISTORICAL COMPLAINTS WERE REVIEWED FOR INFORMATION RELATED TO THE REPORTED COMPLAINT, AND THERE WAS NO PREVIOUS HISTORY OF COMPLAINTS FOR THE ICY CATHETER WITH LOT NUMBER 193912.

Additional Manufacturer Narrative · 0

ZOLL HAS NOT YET RECEIVED THE CATHETER IN COMPLAINT FOR INVESTIGATION. A SUPPLEMENTAL REPORT WILL BE FILED IF AND WHEN THE PRODUCT IS RETURNED AND INVESTIGATION HAS BEEN COMPLETED.

Additional Manufacturer Narrative · 0

THE CATHETER IN THE COMPLAINT WAS RETURNED TO ZOLL ON 18 SEPTEMBER 2024 FOR EVALUATION. HOWEVER, THE INVESTIGATION IS STILL IN PROGRESS. A FOLLOW-UP REPORT WILL BE SUBMITTED WHEN THE INVESTIGATION IS COMPLETED. ONLY LIMITED INFORMATION IS AVAILABLE ABOUT EVENT OF DVT. HOWEVER, EVENT OF DVT WAS ASSESSED AS SERIOUS BECAUSE BASED ON AVAILABLE INFORMATION, TREATMENT WITH HEPARIN WAS REQUIRED. EVENT ASSESSED AS POSSIBLY RELATED TO THE ZOLL CATHETER DUE TO RELEVANT TIMING OF DVT. AT THE SAME TIME, THE CLINICAL CONDITION OF ICU PATIENT AND IMMOBILITY POSSIBLY CONTRIBUTED TO DEVELOPMENT OF CURRENT CONDITION OF DVT. DVT IS A KNOWN COMPLICATION OF CENTRAL CATHETERS OF ANY KIND. PATIENTS IN A CRITICAL CONDITION ARE TREATED WITH IVTM. IN SUCH CASES, THOSE CONDITIONS MAKE THE PATIENTS PREDISPOSED TO THROMBOGENICITY. DEVELOPMENT OF THROMBUS IS A COMMON COMPLICATION IS SUCH PATIENT POPULATION. CRITICALLY ILL PATIENTS ARE AT INCREASED RISK OF VTE BECAUSE OF THE PRESENCE OF MULTIPLE PREDISPOSING FACTORS [W. GEERTS, ET AL. VENOUS THROMBOEMBOLISM AND ITS PREVENTION IN CRITICAL CARE. J CRIT CARE, 17 (2002), PP. 95-104]. THE RATE OF THROMBOSIS FOR CRITICAL CARE PATIENTS RECEIVING CVCS RANGES FROM 20 TO 30%, PATIENTS WITH PERIPHERAL CENTRAL CATHETERS HAD A SIGNIFICANTLY HIGHER INCIDENCE RATE OF DVT THAN PATIENTS WITH CVC (27.2% VS 9.6%, P=0.0012). THE RATE OF DVT IN THE PATIENT POPULATION RECEIVING IVTM POST-CARDIAC ARREST IS 1.7%. FOUR RANDOMIZED CONTROLLED CLINICAL TRIALS CONDUCTED IN A TOTAL OF 943 PATIENTS SHOWED THAT THERE WAS NO DIFFERENCE IN THE DVT RATE WHEN COMPARING ZOLL IVTM CATHETERS TO STANDARD CVCS. THE RATE OF DVT IN THE PATIENT POPULATION RECEIVING SURFACE COOLING HAS BEEN REPORTED BETWEEN 3 AND 15%. TIMELY ADMINISTRATION OF PROPHYLACTIC ANTICOAGULATION IS SAFE AND SIGNIFICANTLY REDUCES DVT RATES IN HIGH-RISK PATIENT POPULATIONS [ZOLL WHITE PAPER ON DVT]. DVT IS ANTICIPATED EVENT AND COULD POTENTIALLY OCCUR WITH USAGE OF ANY CATHETER. THE EVENT IS POSSIBLY RELATED TO THE DEVICE AND NOT RELATED TO THE PROCEDURE.

Description of Event or Problem · 0

A NURSE IN THE ICU CONTACTED ZOLL TO REPORT THAT THE THERMOGARD XP IVTM SYSTEM WAS REPEATEDLY TRIGGERING AIR TRAP ALARMS, INDICATING AIR ACCUMULATION IN THE AIR TRAP CHAMBER OF THE START-UP KIT (SUK). THE ICY CATHETER (LOT #193912) HAD BEEN SMOOTHLY PLACED IN THE PATIENT'S LEFT FEMORAL VEIN WITHOUT ANY OTHER LINES AT THE SAME SITE. THE ZOLL TECHNICAL SUPPORT INSTRUCTED THE NURSE TO CHECK THE SUK CONNECTIONS AND VERIFY ITS CORRECT INSTALLATION. THERE WAS NO EVIDENCE OF SALINE LEAKAGE AROUND THE THERMOGARD CONSOLE OR NEAR THE PATIENT. THE NURSE MENTIONED THAT THE SALINE BAG HAD BEEN DEPLETED ONCE AND SUBSEQUENTLY REPLACED. THE TECHNICAL SUPPORT EMPHASIZED THAT THE SALINE BAG SHOULD NOT BE REPLACED IN THE FUTURE; INSTEAD, ZOLL SHOULD BE CONTACTED IF IT RUNS OUT. THE NURSE WAS INFORMED OF A SUSPECTED LEAK IN THE CATHETER BALLOON AND WAS ADVISED TO HAVE A HEALTHCARE PROVIDER REMOVE THE CATHETER AND CONSIDER INSERTING A NEW ONE. THE PHYSICIAN REMOVED AND REPLACED THE SUSPECTED CATHETER. AFTER THE CATHETER WAS REPLACED, THE AIR TRAP ALARM WAS CLEARED. THE NURSE STATED THAT THE PATIENT HAD DEVELOPED LOWER EXTREMITY DEEP VEIN THROMBOSIS (DVT). THE REPORTING NURSE ADDED THAT SCANS WERE DONE TO DIAGNOSE THE DVT AND HEPARIN WAS STARTED. NO FURTHER INFORMATION WAS PROVIDED.

Description of Event or Problem · 0

A NURSE IN THE ICU CONTACTED ZOLL TO REPORT THAT THE THERMOGARD XP IVTM SYSTEM WAS REPEATEDLY TRIGGERING AIR TRAP ALARMS, INDICATING AIR ACCUMULATION IN THE AIR TRAP CHAMBER OF THE START-UP KIT (SUK). THE QUATTRO CATHETER (LOT #UNKNOWN) HAD BEEN PLACED IN THE PATIENT'S LEFT FEMORAL VEIN WITHOUT ANY OTHER LINES AT THE SAME SITE. THE ZOLL TECHNICAL SUPPORT INSTRUCTED THE NURSE TO CHECK THE SUK CONNECTIONS AND VERIFY ITS CORRECT INSTALLATION. THERE WAS NO EVIDENCE OF SALINE LEAKAGE AROUND THE THERMOGARD CONSOLE OR NEAR THE PATIENT. THE NURSE MENTIONED THAT THE SALINE BAG HAD BEEN DEPLETED ONCE AND SUBSEQUENTLY REPLACED. THE TECHNICAL SUPPORT EMPHASIZED THAT THE SALINE BAG SHOULD NOT BE REPLACED IN THE FUTURE; INSTEAD, ZOLL SHOULD BE CONTACTED IF IT RUNS OUT. THE NURSE WAS INFORMED OF A SUSPECTED LEAK IN THE CATHETER BALLOON AND WAS ADVISED TO HAVE A HEALTHCARE PROVIDER REMOVE THE CATHETER AND CONSIDER INSERTING A NEW ONE. NO FURTHER INFORMATION WAS PROVIDED. THE PATIENT'S STATUS INFORMATION WAS REQUESTED, BUT THE CUSTOMER DID NOT PROVIDE A RESPONSE.

Description of Event or Problem · 0

A NURSE IN THE ICU CONTACTED ZOLL TO REPORT THAT THE THERMOGARD XP IVTM SYSTEM WAS REPEATEDLY TRIGGERING AIR TRAP ALARMS, INDICATING AIR ACCUMULATION IN THE AIR TRAP CHAMBER OF THE START-UP KIT (SUK). THE QUATTRO CATHETER (LOT #UNKNOWN) HAD BEEN SMOOTHLY PLACED IN THE PATIENT'S LEFT FEMORAL VEIN WITHOUT ANY OTHER LINES AT THE SAME SITE. THE ZOLL TECHNICAL SUPPORT INSTRUCTED THE NURSE TO CHECK THE SUK CONNECTIONS AND VERIFY ITS CORRECT INSTALLATION. THERE WAS NO EVIDENCE OF SALINE LEAKAGE AROUND THE THERMOGARD CONSOLE OR NEAR THE PATIENT. THE NURSE MENTIONED THAT THE SALINE BAG HAD BEEN DEPLETED ONCE AND SUBSEQUENTLY REPLACED. THE TECHNICAL SUPPORT EMPHASIZED THAT THE SALINE BAG SHOULD NOT BE REPLACED IN THE FUTURE; INSTEAD, ZOLL SHOULD BE CONTACTED IF IT RUNS OUT. THE NURSE WAS INFORMED OF A SUSPECTED LEAK IN THE CATHETER BALLOON AND WAS ADVISED TO HAVE A HEALTHCARE PROVIDER REMOVE THE CATHETER AND CONSIDER INSERTING A NEW ONE. THE PHYSICIAN REMOVED AND REPLACED THE SUSPECTED CATHETER. AFTER THE CATHETER WAS REPLACED, THE AIR TRAP ALARM WAS CLEARED. THE NURSE STATED THAT THE PATIENT HAD DEVELOPED LOWER EXTREMITY DEEP VEIN THROMBOSIS (DVT). THE REPORTING NURSE ADDED THAT SCANS WERE DONE TO DIAGNOSE THE DVT AND HEPARIN WAS STARTED. NO FURTHER INFORMATION WAS PROVIDED.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
1218085 ICY® INTRAVASCULAR HEAT EXCHANGE CATHETER KIT CUSTOM LUER APPLAUSE (HEPARIN) INTRAVASCULAR CORE TEMPERATURE REGULATION SYSTEM CATHETER NCX ZOLL CIRCULATION, INC. IC-3893 193912 00849111075237

Patients

Seq Age Sex Outcome Treatment
1 NA Unknown Other