FDA Adverse Event Malfunction Summary report: N

BD RESPIRATORY VIRAL PANEL FOR BD MAX¿ SYSTEM

MDR report key: 19999612 · Received August 19, 2024

Report

Report Number
3007420875-2024-00065
Event Type
Malfunction
Date Received
August 19, 2024
Date of Event
July 15, 2024
Report Date
September 26, 2024
Manufacturer
GENEOHM SCIENCES CANADA, INC. (BD DIAGNOSTICS)
Product Code
QOF
UDI-DI
00382904453732
PMA / PMN Number
K230956
Product Problem
Yes
Report Source
Manufacturer report
Reporter Location
NJ, US
Reporter Occupation
OTHER HEALTH CARE PROFESSIONAL
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

A DEVICE EVALUATION IS ANTICIPATED BUT HAS NOT YET BEGUN. UPON COMPLETION OF THE INVESTIGATION, A SUPPLEMENTAL REPORT WILL BE FILED.

Additional Manufacturer Narrative · 0

INVESTIGATION SUMMARY: THE COMPLAINT INVESTIGATION FOR DISCREPANT RESULTS WHEN USING THE BD MAX¿ RESPIRATORY VIRAL PANEL ASSAY (REF. (B)(4) FROM LOT: 4121704 WAS PERFORMED BY THE REVIEW OF MANUFACTURING RECORDS, REVIEW OF CUSTOMER¿S DATA AND BY THE COMPLAINT¿S HISTORY REVIEW. CUSTOMER COMPLAINED ABOUT OBTAINING A COVID POSITIVE RESULT THAT REPEATED AS NEGATIVE WHEN USING THE BD MAX¿ RESPIRATORY VIRAL PANEL KIT LOT: 4121704. A NEGATIVE RESULT WAS ALSO OBTAINED ON THE BIOFIRE PLATFORM. REVIEW OF THE MANUFACTURING RECORDS OF BD MAX¿ RESPIRATORY VIRAL PANEL ASSAY INDICATED THAT LOT: 4121704 WAS MANUFACTURED ACCORDING TO SPECIFICATIONS AND MET PERFORMANCE REQUIREMENTS. CUSTOMER PROVIDED SAMPLE RUNS (B)(4) FROM INSTRUMENT CT1490 THAT WERE ANALYZED. MANUAL PCR CURVE ADJUDICATION WAS CONDUCTED ON THE SAMPLES TARGETED BY THE CLIENT IN RUN (B)(4); POSITION A8 AND RUN (B)(4); POSITION A3. SAMPLE IN RUN (B)(4); POSITION A8 (FIRST TEST) SHOWS A LATE AND LOW BUT TRUE AMPLIFICATION OF THE FAM CHANNEL (COVID TARGET). SAMPLE IN RUN (B)(4); POSITION A3 (REPEAT TEST) SHOWS FLAT CURVES WITHOUT ANY AMPLIFICATION. MANUAL CURVE ADJUDICATION HAS LIMITATIONS; VISUAL EXAMINATION OF PCR CURVES FOR LOW SIGNAL IS A CONSERVATIVE ASSESSMENT OF THE DATA. THERE IS NO INDICATION OF A REAGENT ISSUE BASED ON THE ANALYSIS OF THE COMPLAINTS RECEIVED FOR DISCREPANT RESULTS ON THE BD MAX¿ RESPIRATORY VIRAL PANEL ASSAY LOT: 4121704. THE ROOT CAUSE WAS NOT IDENTIFIED. BASED ON THE DATA AND INFORMATION PROVIDED, SPECIMENS AT OR NEAR THE ASSAY LIMIT OF DETECTION (LOD), OR ENVIRONMENTAL OR CROSS CONTAMINATION, ARE THE MOST LIKELY CAUSES TO EXPLAIN THE CUSTOMER¿S POSITIVE RESULTS. MOREOVER, LIMIT OF DETECTION CAN VARY BETWEEN DIFFERENT ASSAYS WHICH COULD EXPLAIN THE DISCREPANCIES BETWEEN PLATFORMS. BD CANNOT CONFIRM THE COMPLAINT BASED ON THE INVESTIGATION THAT WAS PERFORMED. BD DID NOT INITIATE A CORRECTIVE AND PREVENTIVE ACTION SINCE NO NEW HAZARD OR TRENDS WAS IDENTIFIED. BD APOLOGIZES FOR THE INCONVENIENCE THAT THIS MAY HAVE CAUSED. BD QUALITY WILL CONTINUE TO MONITOR FOR TRENDS.

Description of Event or Problem · 0

IT WAS REPORTED THAT DURING USE OF BD RESPIRATORY VIRAL PANEL FOR BD MAX¿ SYSTEM, A DISCREPANT PATIENT COVID RESULT WAS OBTAINED. THE SAMPLE WAS POSITIVE, BUT THEN UPON REPEAT IT WAS NEGATIVE. THERE WAS NO REPORT OF PATIENT IMPACT.

Description of Event or Problem · 0

IT WAS REPORTED THAT DURING USE OF BD RESPIRATORY VIRAL PANEL FOR BD MAX¿ SYSTEM, A DISCREPANT PATIENT COVID RESULT WAS OBTAINED. THE SAMPLE WAS POSITIVE, BUT THEN UPON REPEAT IT WAS NEGATIVE. THERE WAS NO REPORT OF PATIENT IMPACT.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
2398191 BD RESPIRATORY VIRAL PANEL FOR BD MAX¿ SYSTEM MULTIPLE-GENUS RESPIRATORY VIRUS NUCLEIC ACID IVD, KIT, NUCLEIC ACID TECHNIQUE QOF GENEOHM SCIENCES CANADA, INC. (BD DIAGNOSTICS) 4121704 00382904453732

Patients

Seq Age Sex Outcome Treatment
1 NA Unknown