FDA Adverse Event Injury Summary report: N

ORGANOX METRA

MDR report key: 19780106 · Received July 18, 2024

Report

Report Number
3022300078-2024-00014
Event Type
Injury
Date Received
July 18, 2024
Date of Event
June 20, 2024
Report Date
August 14, 2024
Manufacturer
ORGANOX LIMITED
Product Code
QQK
UDI-DI
05060462240029
Adverse Event
Yes
Product Problem
Yes
Report Source
Distributor report
Reporter Location
FL, US
Reporter Occupation
PHYSICIAN
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

THE DISPOSABLE SET WAS RETURNED ON JULY 2, 2024. THE ROOT CAUSE INVESTIGATION IS PENDING. A FOLLOW REPORT WILL BE SUBMITTED ONCE ADDITIONAL INFORMATION IS AVAILABLE.

Additional Manufacturer Narrative · 0

A SERVICE ENGINEER (SE) EVALUATED THE DEVICE AT THE CUSTOMER SITE. NO PHYSICAL DEFECTS WERE IDENTIFIED. THE PINCH VALVES HAD NO SIGNS OF BLOOD INGRESS AND MOVED FREELY. THE SE TESTED THE DEVICE FLOW AT PREP MODE. NO ISSUES WERE OBSERVED. STABLE FLOWS WERE CONFIRMED DURING LIVER ON BOARD MODE WITH A SERVICE SET. NO ISSUES IDENTIFIED DURING THE DEVICE EVALUATION. REVIEW OF DEVICE EVENT DATA CONCLUDED FLOWS WERE AS EXPECTED DURING THE REPORTED EVENT WHEN THE DEVICE WAS IN PREPARATION MODE, BUT THE ARTERIAL PRESSURE WAS LOW. LOW ARTERIAL PRESSURE COULD HAVE BEEN CAUSED BY A KINK IN THE ARTERIAL LINE, BUT THIS COULD NOT BE CONFIRMED. NO NOTABLE FLOW WAS ACHIEVED FOR THE 24 MINUTES OF THE INITIAL PERFUSION PER THE RESULTS OF THE DATA REVIEW. THE ROOT CAUSE OF THE REPORTED EVENT IS UNDETERMINED CURRENTLY. THE DISPOSABLE SET USED DURING THE REPORTED EVENT WAS RETURNED TO THE MANUFACTURE AND THEN SENT TO THE SUPPLIER. A SUPPLIER CORRECTIVE ACTION REQUEST (SCAR) HAS BEEN INITIATED. THE SCAR FINDINGS ARE PENDING.

Description of Event or Problem · 0

THE DEVICE USER (DU) REPORTED THAT THERE WAS LITTLE TO NO FLOW NOTED AFTER THE LIVER WAS CONNECTED TO THE DEVICE. DURING TROUBLESHOOTING A DARKENED AREA AT THE TOP OF THE SOFT-SHELL RESERVOIR WAS NOTED AND AIR WAS OBSERVED IN THE TUBING. THE DECISION WAS MADE TO REMOVE THE LIVER AND COLD FLUSH TO AVOID WARM ISCHAEMIA TIME. FOLLOWING ADDITIONAL TROUBLESHOOTING, THE DU DISCOVERED A CLOT IN THE PORTAL CANNULA. THE DEVICE WAS CLEARED OF AIR AND PREPARATION MODE WAS ACHIEVED. IT WAS CONFIRMED THAT THE DU USED THE RECOMMENDED INFUSIONS, BOLUS DRUGS & PRIMING STEPS. ABOUT ONE HOUR LATER THE DU REPORTED THAT THE DEVICE ENTERED LOW RESERVOIR MODE. THIS WAS RESOLVED BY MANIPULATING THE RECIRCULATION PUMP SENSOR RESULTING IN THE VOLUME IN THE BOWL RECIRCULATING INTO THE RESERVOIR. ULTIMATELY, THE DU DECIDED TO DISCARD THE DONOR LIVER DUE TO FAILURE TO CLEAR LACTATE AND FAILURE TO MAINTAIN PH EVEN THOUGH THE FLOWS WERE FINE ONCE THE CLOT WAS REMOVED.

Description of Event or Problem · 0

THE DEVICE USER (DU) REPORTED THAT THERE WAS LITTLE TO NO FLOW NOTED AFTER THE LIVER WAS CONNECTED TO THE DEVICE. DURING TROUBLESHOOTING A DARKENED AREA AT THE TOP OF THE SOFT SHELL RESERVOIR WAS NOTED AND AIR WAS OBSERVED IN THE TUBING. THE DECISION WAS MADE TO REMOVE THE LIVER AND COLD FLUSH TO AVOID WARM ISCHAEMIA TIME. FOLLOWING ADDITIONAL TROUBLESHOOTING, THE DU DISCOVERED A CLOT IN THE PORTAL CANNULA. THE DEVICE WAS CLEARED OF AIR AND PREPARATION MODE WAS ACHIEVED. IT WAS CONFIRMED THAT THE DU USED THE RECOMMENDED INFUSIONS, BOLUS DRUGS & PRIMING STEPS. ABOUT ONE HOUR LATER THE DU REPORTED THAT THE DEVICE ENTERED LOW RESERVOIR MODE. THIS WAS RESOLVED BY MANIPULATING THE RECIRCULATION PUMP SENSOR RESULTING IN THE VOLUME IN THE BOWL RECIRCULATING INTO THE RESERVOIR. ULTIMATELY, THE DU DECIDED TO DISCARD THE DONOR LIVER DUE TO FAILURE TO CLEAR LACTATE AND FAILURE TO MAINTAIN PH EVEN THOUGH THE FLOWS WERE FINE ONCE THE CLOT WAS REMOVED.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
1645239 ORGANOX METRA NORMOTHERMIC MACHINE PERFUSION SYSTEM FOR THE PRESERVATION OF DONOR LIVERS PRIOR QQK ORGANOX LIMITED 11146868 05060462240029

Patients

Seq Age Sex Outcome Treatment
1 NA Unknown Other