FDA Adverse Event Injury Summary report: N

EDWARDS INSPIRIS RESILIA AORTIC VALVE

MDR report key: 19620971 · Received June 26, 2024

Report

Report Number
2015691-2024-04905
Event Type
Injury
Date Received
June 26, 2024
Report Date
July 31, 2024
Manufacturer
EDWARDS LIFESCIENCES
Product Code
LWR
PMA / PMN Number
P150048
Adverse Event
Yes
Report Source
Manufacturer report
Reporter Location
US
Reporter Occupation
PHYSICIAN
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

UPDATED SECTIONS: G3, G6, H6 INVESTIGATION FINDINGS, AND INVESTIGATION CONCLUSIONS. THE DEVICE HISTORY RECORD (DHR) WAS UNABLE TO BE PERFORMED, AS THE DEVICE LOT/SERIAL NUMBER WAS NOT PROVIDED. TISSUE DEGENERATION-RELATED STRUCTURAL DETERIORATION, EITHER CALCIFIC OR NON-CALCIFIC, ARE COMMON CHRONIC FAILURE MODES FOR THIS TYPE OF BIOPROSTHETIC HEART VALVE. OPERATIONAL MECHANICAL STRESS AND BIOLOGICAL FACTORS ARE GENERALLY BELIEVED TO BE THE MAJOR CONTRIBUTORS TO THE NON-CALCIFIC BIOPROSTHETIC TISSUE DEGENERATION. STRUCTURAL VALVE DETERIORATION (SVD) CAN, AND TYPICALLY DOES, LEAD TO CHRONIC CENTRAL LEAKS OVER A PERIOD OF TIME. SVD IS THE MOST COMMON REASON FOR BIOPROSTHESIS EXPLANT AND ENCOMPASSES MULTIPLE FAILURE MODES, INCLUDING CALCIFICATION, NONCALCIFIC DEGENERATION, DEHISCENCE, CUSP THICKENING OR FIBROSIS, OR A COMBINATION OF THESE. SUCH FAILURE MODES MAY OCCUR SINGULARLY OR CONCOMITANTLY. A DEFINITIVE ROOT CAUSE CANNOT BE CONCLUSIVELY DETERMINED; HOWEVER, PATIENT FACTORS LIKELY CAUSED OR CONTRIBUTED TO THE EVENT.

Additional Manufacturer Narrative · 0

UPDATED SECTIONS: B5, B6, G3, G6, H6 HEALTH EFFECT - CLINICAL CODE, AND TYPE OF INVESTIGATION. ARTICLE CITATION: HIROTA, M, DOMOTO, S, INAGAKI, Y. ET AL. TRANSCATHETER SELF-EXPANDABLE AORTIC VALVE IMPLANTATION IN THE EXPANDABLE SURGICAL AORTIC VALVE. J AM COLL CARDIOL INTV. 024 JUN,17 (11) 1397-1399. HTTPS://DOI.ORG/10.1016/J.JCIN.2024.04.009.

Additional Manufacturer Narrative · 0

THE SUBJECT DEVICE IS NOT AVAILABLE FOR EVALUATION, AS IT REMAINS IMPLANTED IN THE PATIENT. THE INVESTIGATION IS STILL IN PROGRESS; THEREFORE, A CONCLUSION HAS YET TO BE ESTABLISHED. A SUPPLEMENTAL REPORT WILL BE SUBMITTED ACCORDINGLY UPON INVESTIGATION COMPLETION. EDWARDS WILL CONTINUE TO REVIEW AND MONITOR ALL REPORTED EVENTS. TRENDS ARE MONITORED ON A MONTHLY BASIS AND IF ACTION IS REQUIRED, APPROPRIATE INVESTIGATION WILL BE PERFORMED.

Description of Event or Problem · 0

EDWARDS REVIEWED THE LITERATURE ARTICLE, TRANSCATHETER SELF-EXPANDABLE AORTIC VALVE IMPLANTATION IN THE EXPANDABLE SURGICAL AORTIC VALVE, IN JACC: CARDIOVASCULAR INTERVENTIONS. VOL 17, NO. 11, 2024. EDWARDS RECEIVED INFORMATION THAT A PATIENT WITH A 19MM 11500AJ AORTIC VALVE IMPLANTED APPROXIMATELY SIX (6) YEARS UNDERWENT VALVE-IN-VALVE PROCEDURE DUE TO AORTIC STENOSIS SECONDARY TO SEVERE STRUCTURAL VALVE DETERIORATION. SYMPTOMS OF HEART FAILURE AND DYSPNEA WAS SEEN. THE ELECTROCARDIOGRAM SHOWED A COMPLETELY RIGHT BUNDLE BLOCK. THE DEVICE WAS REPLACED WITH A NON-EDWARDS VALVE WITHOUT ANY ADVERSE EVENT REPORTED. PATIENT WAS DISCHARGED FROM THE HOSPITAL.

Description of Event or Problem · 0

EDWARDS RECEIVED INFORMATION THAT A PATIENT WITH A 19MM 11500AJ AORTIC VALVE IMPLANTED APPROXIMATELY SIX (6) YEARS UNDERWENT VALVE-IN-VALVE PROCEDURE DUE TO AORTIC STENOSIS SECONDARY TO STRUCTURAL VALVE DETERIORATION. SYMPTOMS OF HEART FAILURE AND DYSPNEA WAS SEEN. THE DEVICE WAS REPLACED WITH A NON-EDWARDS VALVE WITHOUT ANY ADVERSE EVENT REPORTED. PATIENT WAS DISCHARGED FROM THE HOSPITAL.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
430451 EDWARDS INSPIRIS RESILIA AORTIC VALVE HEART-VALVE, NON-ALLOGRAFT TISSUE LWR EDWARDS LIFESCIENCES 11500AJ

Patients

Seq Age Sex Outcome Treatment
1 83 YR Female Required Intervention| L| H