FDA Adverse Event Malfunction Summary report: N

ALINITY HQ PROCESSING MODULE

MDR report key: 18326790 · Received December 14, 2023

Report

Report Number
2919069-2023-00049
Event Type
Malfunction
Date Received
December 14, 2023
Date of Event
November 14, 2023
Report Date
June 27, 2024
Manufacturer
ABBOTT LABORATORIES
Product Code
GKZ
UDI-DI
00380740138851
PMA / PMN Number
K220031
Product Problem
Yes
Report Source
Manufacturer report
Reporter Location
NO
Reporter Occupation
OTHER HEALTH CARE PROFESSIONAL
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

AN EVALUATION IS IN PROCESS. A FOLLOW-UP REPORT WILL BE SUBMITTED WHEN THE EVALUATION IS COMPLETE. COMPLETE INFORMATION FOR SECTION A1 PATIENT IDENTIFIER IS SID (B)(6) AND SID (B)(6).

Additional Manufacturer Narrative · 0

CORRECTION WAS MADE TO FIELD D2B PRO CODE. THE INCORRECT CODE OF GRZ WAS CHANGED TO GKZ. THIS WAS A TYPOGRAPHICAL ERROR CORRECTION AND THERE IS NO FURTHER IMPACT TO THE SUBMISSION. ADDITIONAL INFORMATION PROVIDED IN SECTION D4 PRIMARY UDI NUMBER: (B)(4)

Additional Manufacturer Narrative · 0

THE COMPLAINT INVESTIGATION FOR DISCREPANT RESULTS GENERATED ON THE ALINITY HQ PROCESSING MODULE, SERIAL NUMBER (B)(6), INCLUDED A REVIEW OF DATA AND INFORMATION PROVIDED BY THE CUSTOMER, SEARCH FOR SIMILAR COMPLAINTS, TICKET TRENDING REVIEW, LABELING REVIEW, AND DEVICE HISTORY RECORD REVIEW. RETURN TESTING WAS NOT COMPLETED AS RETURNS WERE NOT AVAILABLE. TRENDING REVIEW DID NOT IDENTIFY ANY TRENDS FOR THE ISSUE FOR THE PRODUCT. A REVIEW OF THE MANUFACTURING DOCUMENTATION DID NOT IDENTIFY ANY ISSUES ASSOCIATED WITH THE COMPLAINT ISSUE. LABELING WAS REVIEWED AND SUFFICIENTLY ADDRESSES THE CUSTOMER'S ISSUE. REVIEW OF THE DATA FOUND THAT THE LYM, MONO, BASO, RBC, HCT, MCV, MCH, MCHC, RDW, PLT, AND MPV PARAMETERS WERE FLAGGED AS SUSPECT/INVALID AND BLAST, RBC FRAGMENTS, AND BASO BOUNDARY NOT FOUND FLAGS WERE GENERATED FOR ALL SAMPLE RUNS. ADDITIONALLY, MONO BOUNDARY NOT FOUND FLAG WAS GENERATED FOR SEQ 88893 AND PLT CLUMP FLAG WAS GENERATED FOR SEQ 89024. REVIEW THE RESULTS BETWEEN SAMPLE ID (B)(6) (ASSUMING TWO DIFFERENT SAMPLES FROM THE SAME PATIENT) FOUND WBC, RBC, HGB, PLT WERE ALL LOWER FOR THE SECOND SAMPLE (ID (B)(6)). REVIEW OF THE FCS FILES FOR BOTH SAMPLES FOUND THAT THERE WAS NO CLEAR SEPARATION BETWEEN NEU, MONO, AND LYM POPULATIONS. BLAST FLAGGING WAS GENERATED. PER THE OPERATOR¿S MANUAL, BLAST CELLS CAN MAKE SOME WBC DIFFERENTIAL RESULTS SUSPECT OR INVALID BASED ON THE NUMBER OF BLASTS. IN THIS CASE, THE MONO COUNTS WERE INVALIDATED AND LYM RESULTS WERE SUSPECTED. WHEN WBC DIFFERENTIAL WAS INVALIDATED/SUSPECTED FOR ANY PART, THE VERIFICATION OF ALL WBC DIFFERENTIALS WOULD BE REQUIRED. BASED ON THE INFORMATION PROVIDED, THE SPECIFIC PATHOLOGY OF THIS SAMPLE COULD NOT BE RULED OUT AS A CONTRIBUTING FACTOR TO THE CAUSE OF THIS ISSUE. THE ALINITY HQ GENERATED MORPHOLOGICAL FLAGGING AND MARKED THE RESULTS AS SUSPECT, INDICATING THAT VERIFICATION OF THE RESULTS WAS REQUIRED. BASED ON OUR INVESTIGATION, NO SYSTEMIC ISSUE OR DEFICIENCY WITH THE ALINITY HQ PROCESSING MODULE FOR SERIAL NUMBER (B)(6) WAS IDENTIFIED.

Description of Event or Problem · 0

THE CUSTOMER OBSERVED IMPRECISE NEUTROPHIL COUNTS AND HEMOGLOBIN RESULTS FOR ONE PATIENT ON AN ALINITY HQ ANALYZER. THE PATIENT HAS MDS AND THE CUSTOMER EXPECTED THE NEUTROLPHIL RESULTS TO BE FLAGGED AND INVALIDATED ON THE ALINITY HQ. THE SAME PATIENT WAS RAN IN DUPLICATE TWO DAYS IN A ROW WITH VARYING NEUTROPHIL AND HEMOGLOBIN RESULTS. THE FOLLOWING DATA WAS PROVIDED (CUSTOMER¿S NORMAL RANGE FOR NEUTROPHIL IS 1.8-6.9 10E9/L): SID (B)(6) (B)(6) 2023 10:13AM NEUT = 0.094 X10^9/L HEMOGLOBIN RESULT = 10.2 G/DL. SID (B)(6) (B)(6) 2023 10:17AM NEUT = 2.11 X10^9/L HEMOGLOBIN RESULT = 10.2 G/DL. SID (B)(6) (B)(6) 2023 10:17AM NEUT = 1.59 X10^9/L HEMOGLOBIN RESULT = 7.90 G/DL. SID (B)(6) (B)(6) 2023 10:17AM NEUT = 0.294 X10^9/L HEMOGLOBIN RESULT = 7.96 G/DL THERE WAS NO IMPACT TO PATIENT MANAGEMENT REPORTED.

Description of Event or Problem · 0

THE CUSTOMER OBSERVED IMPRECISE NEUTROPHIL COUNTS AND HEMOGLOBIN RESULTS FOR ONE PATIENT ON AN ALINITY HQ ANALYZER. THE PATIENT HAS MDS AND THE CUSTOMER EXPECTED THE NEUTROLPHIL RESULTS TO BE FLAGGED AND INVALIDATED ON THE ALINITY HQ. THE SAME PATIENT WAS RAN IN DUPLICATE TWO DAYS IN A ROW WITH VARYING NEUTROPHIL AND HEMOGLOBIN RESULTS. THE FOLLOWING DATA WAS PROVIDED (CUSTOMER¿S NORMAL RANGE FOR NEUTROPHIL IS 1.8-6.9 10E9/L): SID (B)(6),ON (B)(6) 2023 ,10:13AM NEUT = 0.094 X10^9/L HEMOGLOBIN RESULT = 10.2 G/DL. SID (B)(6), ON (B)(6) 2023 ,10:17AM NEUT = 2.11 X10^9/L HEMOGLOBIN RESULT = 10.2 G/DL. SID (B)(6) , ON (B)(6) 2023, 10:17AM NEUT = 1.59 X10^9/L HEMOGLOBIN RESULT = 7.90 G/DL. SID (B)(6), ON (B)(6) 2023, 10:17AM NEUT = 0.294 X10^9/L HEMOGLOBIN RESULT = 7.96 G/DL THERE WAS NO IMPACT TO PATIENT MANAGEMENT REPORTED.

Description of Event or Problem · 0

THE CUSTOMER OBSERVED IMPRECISE NEUTROPHIL COUNTS AND HEMOGLOBIN RESULTS FOR ONE PATIENT ON AN ALINITY HQ ANALYZER. THE PATIENT HAS MDS AND THE CUSTOMER EXPECTED THE NEUTROLPHIL RESULTS TO BE FLAGGED AND INVALIDATED ON THE ALINITY HQ. THE SAME PATIENT WAS RAN IN DUPLICATE TWO DAYS IN A ROW WITH VARYING NEUTROPHIL AND HEMOGLOBIN RESULTS. THE FOLLOWING DATA WAS PROVIDED (CUSTOMER¿S NORMAL RANGE FOR NEUTROPHIL IS 1.8-6.9 10E9/L): SID (B)(6) 14NOV2023 10:13AM NEUT = 0.094 X10^9/L HEMOGLOBIN RESULT = 10.2 G/DL. SID (B)(6) 14NOV2023 10:17AM NEUT = 2.11 X10^9/L HEMOGLOBIN RESULT = 10.2 G/DL. SID (B)(6) 15NOV2023 10:17AM NEUT = 1.59 X10^9/L HEMOGLOBIN RESULT = 7.90 G/DL. SID (B)(6) 15NOV2023 10:17AM NEUT = 0.294 X10^9/L HEMOGLOBIN RESULT = 7.96 G/DL THERE WAS NO IMPACT TO PATIENT MANAGEMENT REPORTED.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
1227417 ALINITY HQ PROCESSING MODULE COUNTER, DIFFERENTIAL CELL GKZ ABBOTT LABORATORIES 00380740138851
266450 ALINITY HQ PROCESSING MODULE COUNTER, DIFFERENTIAL CELL GKZ ABBOTT LABORATORIES 00380740138851

Patients

Seq Age Sex Outcome Treatment
1 NA Unknown