FDA Adverse Event Malfunction Summary report: N

VITROS XT 7600 INTEGRATED SYSTEM

MDR report key: 16230175 · Received January 23, 2023

Report

Report Number
0001319681-2023-00006
Event Type
Malfunction
Date Received
January 23, 2023
Date of Event
December 21, 2022
Report Date
January 23, 2023
Manufacturer
ORTHO-CLINICAL DIAGNOSTICS, INC.
Product Code
JJE
UDI-DI
10758750031610
Product Problem
Yes
Report Source
Manufacturer report
Reporter Location
MT, US
Reporter Occupation
OTHER HEALTH CARE PROFESSIONAL
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

THE INVESTIGATION DETERMINED THAT HIGHER AND LOWER THAN EXPECTED PHENOBARBITAL (PHBR) RESULTS WERE OBTAINED FROM ONE LEVEL OF VITROS THERAPEUTIC DRUG MONITORING PERFORMANCE VERIFIER FLUID USING VITROS CHEMISTRY PRODUCTS PHBR SLIDES LOT: 2504-0091-9523 AND 2507-0092-5123 ON A VITROS XT 7600 INTEGRATED SYSTEM. THE ASSIGNABLE CAUSE OF THE HIGHER AND LOWER THAN EXPECTED RESULTS IS MOST LIKELY AN ANALYZER RELATED ISSUE. AN ORTHO FIELD ENGINEER (FE) IS RETURNING TO THE CUSTOMER SITE TO PERFORM TROUBLESHOOTING STEPS THAT ARE EXPECTED TO RESOLVE THE ISSUE AND RETURN THE VITROS XT7600 TO ACCEPTABLE PERFORMANCE. VITROS CRBM PRECISION TESTING PERFORMED ON THE ANALYZER (J76000661) WAS ACCEPTABLE, INDICATING THAT THE IR WASH SYSTEM WAS PERFORMING AS EXPECTED, HOWEVER PRECISION TESTS USING TWO DIFFERENT LOTS OF VITROS PHBR WERE OUTSIDE ORTHO ACCEPTABLE GUIDELINES, INDICATING AN ISSUE WITH THE ANALYZER IN COMBINATION WITH THE VITROS PHBR ASSAY. VITROS PHBR IS SENSITIVE TO SAMPLE VOLUME AND POSITION, INCUBATOR TEMPERATURE AND EVAPORATION, ENVIRONMENTAL TEMPERATURE AND HUMIDITY, IWF METERING AND POSITION, AND IWF HANDLING. AN ISSUE WITH VITROS PHBR LOT: 2504-0091-9523 CANNOT BE FULLY RULED OUT AS A CONTRIBUTOR TO THE EVENT, AS THIS LOT OF VITROS PHBR PRODUCED RESULTS THAT WERE OUTSIDE ORTHO ACCEPTABLE GUIDELINES ON BOTH VITROS XT7600 SYSTEMS AT THE CUSTOMER SITE. AS ALTERNATE VITROS PHBR LOT: 2507-0092-5123 PRODUCED UNACCEPTABLE RESULTS ON ONLY J76000661 BUT ACCEPTABLE RESULTS ON J76000652, THE ISSUE IS ISOLATED TO J76000661 AND VITROS PHBR LOT: 2504-0091-9523. IT IS POSSIBLE THAT THERE IS A PERFORMANCE ISSUE WITH THIS LOT OF SLIDES IN USE AT THIS CUSTOMER SITE ONLY, ALTHOUGH THIS IS UNABLE TO BE CONFIRMED. HOWEVER, CONTINUAL TRACKING AND TRENDING DOES NOT INDICATE A SYSTEMIC ISSUE WITH VITROS PHBR LOT: 2504-0091-9523.

Description of Event or Problem · 0

A CUSTOMER CONTACTED THE ORTHO CLINICAL DIAGNOSTICS (ORTHO) TECHNICAL SOLUTION CENTER (TSC) TO REPORT HIGHER AND LOWER THAN EXPECTED PHENOBARBITAL (PHBR) RESULTS WERE OBTAINED FROM ONE LEVEL OF VITROS THERAPEUTIC DRUG MONITORING PERFORMANCE VERIFIER FLUID USING VITROS CHEMISTRY PRODUCTS PHBR SLIDES LOT: 2504-0091-9523 AND 2507-0092-5123 ON A VITROS XT 7600 INTEGRATED SYSTEM. VITROS PHBR LOT: 2504-0091-9523 VITROS TDM III LOT: U9721 RESULTS OF 78.77, 49.30, 48.23, 49.04, AND 76.16 UG/ML VS AN EXPECTED RESULT OF 62.67 UG/ML VITROS PHBR LOT: 2507-0092-5123 VITROS TDM III LOT: U9721 RESULTS OF 74.97 AND 73.05 UG/ML VS AN EXPECTED RESULT OF 60.18 UG/ML BIASED RESULTS OF THE MAGNITUDE AND DIRECTION OBSERVED MAY LEAD TO INAPPROPRIATE PHYSICIAN ACTION IF THEY WERE TO OCCUR UNDETECTED ON PATIENT SAMPLES. THE HIGHER AND LOWER THAN EXPECTED VITROS PHBR RESULTS WERE OBTAINED FROM A QUALITY CONTROL FLUID AND NO RESULTS WERE REPORTED FROM THE LABORATORY. NO PATIENT SAMPLES WERE PROCESSED AS THE ASSAY WAS BEING VALIDATED AT THE TIME OF THE EVENT. ORTHO HAS NOT BEEN MADE AWARE OF ANY ALLEGATION OF PATIENT HARM AS A RESULT OF THIS EVENT. THIS REPORT CORRESPONDS TO ORTHO CLINICAL DIAGNOSTICS INC (ORTHO) COMPLAINT NUMBER: (B)(4).

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
616199 VITROS XT 7600 INTEGRATED SYSTEM IN-VITRO DIAGNOSTICS JJE ORTHO-CLINICAL DIAGNOSTICS, INC. 6844461 10758750031610

Patients

Seq Age Sex Outcome Treatment
1 Unknown