FDA Adverse Event Malfunction Summary report: N

CEPHEID XPERT XPRESS COV-2/FLU/RSV PLUS

MDR report key: 15407781 · Received September 12, 2022

Report

Report Number
3004530258-2022-00088
Event Type
Malfunction
Date Received
September 12, 2022
Date of Event
August 15, 2022
Report Date
September 12, 2022
Manufacturer
CEPHEID
Product Code
QJR
PMA / PMN Number
EUA210505
Product Problem
Yes
Report Source
Manufacturer report
Reporter Location
CO, US
Reporter Occupation
501

Narratives

Additional Manufacturer Narrative · 0

US CUSTOMER CONTACTED CEPHEID TO DISCUSS PATIENT RESULTS. ON (B)(6) 2022, CUSTOMER REPORTED THAT A PATIENT SAMPLE TESTED AT UNKNOWN DATE AND TIME HAD ENCOUNTERED A SARS COV-2 POS/ FLU A POS/ FLU B POS/ RSV NEG RESULT ON XPRESS SARS COV-2/FLU/RSV PLUS ADF 1 LOT UNKNOWN. THE MEDICAL TEAM THOUGHT IT WAS ODD TO HAVE THAT COMBINATION IF RESULTS AND REQUESTED A TECHNICIAN TO RUN QC. QC WAS SUCCESSFULLY RUN, AND THEY RE-RAN THE ORIGINAL SAMPLE ON AN UNKNOWN DATE AND TIME ON XPRESS SARS COV-2/FLU/RSV PLUS ADF 1 LOT UNKNOWN, WHICH RESULTED IN SARS COV-2 NEG/ FLU A NEG/ FLU B NEG/ RSV NEG. THE SAME PATIENT SAMPLE WAS IN A DIFFERENT LAB AND RECEIVED NEGATIVE RESULTS. CUSTOMER UNABLE TO PROVIDE DATA OR ADDITIONAL INFORMATION REGARDING THE SAMPLE WITHIN THE ALLOTTED TIME. THIS IS A CASE WHEREBY A PATIENT SAMPLE WAS RESULTED WITH SARS-COV-2 AND FLU A&B POSITIVE/DETECTED WITH ALL TARGETS BEING NEGATIVE UPON REPEAT. WE DID NOT RECEIVE GXX/NXX FILES FOR BOTH RESULTS AND UNABLE TO CONCLUDE ON A PROBABLE ROOT CAUSE. POSSIBLE ROOT CAUSES ARE: CONTAMINATION OF THE TEST WITH OTHER TARGETS DURING PRE-ANALYTICAL PHASE. RANDOM CARTRIDGE ERROR CREATING NOISE - PARTICULATES, IMPROPER TUBE FILL, LEAKS. RANDOM INSTRUMENT ERROR CREATING A NOISE - MODULE OPTICS, ELECTRICAL SURGE. MULTIPLE ATTEMPTS TO CONTACT THE CUSTOMER TO OBTAIN MORE INFORMATION INCLUDING THE LOT NUMBER AND DISCUSS THE CASE HAVE BEEN UNANSWERED. SHOULD ADDITIONAL INFORMATION BE RECEIVED IN THE FUTURE, A SUPPLEMENTAL REPORT WILL BE SUBMITTED. FALSE POSITIVE: FALSE POSITIVE RESULTS FOR SARS-COV-2 COULD LEAD TO INCORRECT MANAGEMENT OF SYMPTOMATIC PATIENTS, INCLUDING UNNECESSARY ISOLATION OR QUARANTINE, MISALLOCATION OF RESOURCES, DELAYED DIAGNOSIS AND TREATMENT FOR OTHER INFECTIONS OR HEALTH CONDITIONS, OR UNNECESSARY ANTIVIRAL TREATMENT. CEPHEID'S PATIENT SAFETY BOARD CONSULT CONFIRMED WITH THE CUSTOMER THAT THERE WAS NO ASSOCIATED PATIENT HARM OR CHANGE TO PATIENT TREATMENT. RESULTS ARE FOR THE IDENTIFICATION OF SARS-COV-2 RNA. AS PER SECTION 3 OF THE XPERT XPRESS COV-2/FLU/RSV PLUS EUA IFU; "POSITIVE RESULTS ARE INDICATIVE OF ACTIVE INFECTION, BUT DO NOT RULE OUT BACTERIAL INFECTION OR CO-INFECTION WITH OTHER PATHOGENS NOT DETECTED BY THE TEST. CLINICAL CORRELATION WITH PATIENT HISTORY AND OTHER DIAGNOSTIC INFORMATION IS NECESSARY TO DETERMINE PATIENT INFECTION STATUS." NOTE FOR DEVICE EVALUATED BY MANUFACTURER - ANSWER OF NO IS DUE TO THE SINGLE USE OF THE XPERT XPRESS COV-2/FLU/RSV PLUS TEST AND THE UNAVAILABILITY OF THAT PRODUCT LOT TO BE RETURNED TO CEPHEID.

Description of Event or Problem · 0

US CUSTOMER CONTACTED CEPHEID TO DISCUSS PATIENT RESULTS. ON (B)(6) 2022, CUSTOMER REPORTED THAT A PATIENT SAMPLE TESTED AT UNKNOWN DATE AND TIME HAD ENCOUNTERED A SARS COV-2 POS/ FLU A POS/ FLU B POS/ RSV NEG RESULT ON XPRESS SARS COV-2/FLU/RSV PLUS ADF 1 LOT UNKNOWN. THE MEDICAL TEAM THOUGHT IT WAS ODD TO HAVE THAT COMBINATION IF RESULTS AND REQUESTED A TECHNICIAN TO RUN QC. QC WAS SUCCESSFULLY RUN, AND THEY RE-RAN THE ORIGINAL SAMPLE ON AN UNKNOWN DATE AND TIME ON XPRESS SARS COV-2/FLU/RSV PLUS ADF 1 LOT UNKNOWN, WHICH RESULTED IN SARS COV-2 NEG/ FLU A NEG/ FLU B NEG/ RSV NEG. THE SAME PATIENT SAMPLE WAS IN A DIFFERENT LAB AND RECEIVED NEGATIVE RESULTS. CUSTOMER UNABLE TO PROVIDE DATA OR ADDITIONAL INFORMATION REGARDING THE SAMPLE WITHIN THE ALLOTTED TIME.

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
2392389 CEPHEID XPERT XPRESS COV-2/FLU/RSV PLUS COVID-19 RT-PCR TEST QJR CEPHEID

Patients

Seq Age Sex Outcome Treatment
1 Unknown