FDA Adverse Event Death Summary report: N

PIPELINE

MDR report key: 13519426 · Received February 13, 2022

Report

Report Number
2029214-2022-00215
Event Type
Death
Date Received
February 13, 2022
Date of Event
August 19, 2021
Report Date
February 13, 2022
Manufacturer
MICRO THERAPEUTICS, INC. DBA EV3
Product Code
OUT
Adverse Event
Yes
Report Source
Manufacturer report
Reporter Location
CH
Reporter Occupation
OTHER

Narratives

Additional Manufacturer Narrative · 0

LIANG, F., MA, C., ZHU, H., LIU, L., LIANG, S., JIANG, P., ZHANG, Y., & JIANG, C. (2021). USING ANGIOGRAPHIC PARAMETRIC IM AGING-DERIVED RADIOMICS FEATURES TO PREDICT COMPLICATIONS AND EMBOLIZATION OUTCOMES OF INTRACRANIAL ANEURYSMS TREATED BY PIPELINE EMBOLIZATION DEVICES. JOURNAL OF NEUROINTERVENTIONAL SURGERY. HTTPS://DOI.ORG/10.1136/NEURINTSURG-2021-017832. AGE: THIS VALUE IS THE AVERAGE AGE OF THE PATIENTS REPORTED IN THE ARTICLE AS SPECIFIC PATIENTS COULD NOT BE IDENTIFIED. SEX: THIS VALUE REFLECTS THE GENDER OF THE MAJORITY OF THE PATIENTS REPORTED IN THE ARTICLE AS SPECIFIC PATIENTS COULD NOT BE IDENTIFIED. DATE OF EVENT: PLEASE NOTE THAT THIS DATE IS BASED OFF OF THE DATE OF PUBLICATION OF THE ARTICLE AS THE EVENT DATES WERE NOT PROVIDED IN THE PUBLISHED LITERATURE. IF INFORMATION IS PROVIDED IN THE FUTURE, A SUPPLEMENTAL REPORT WILL BE ISSUED.

Additional Manufacturer Narrative · 0

LIANG, F., MA, C., ZHU, H., LIU, L., LIANG, S., JIANG, P., ZHANG, Y., & JIANG, C. (2021). USING ANGIOGRAPHIC PARAMETRIC IM AGING-DERIVED RADIOMICS FEATURES TO PREDICT COMPLICATIONS AND EMBOLIZATION OUTCOMES OF INTRACRANIAL ANEURYSMS TREATED BY PIPELINE EMBOLIZATION DEVICES. JOURNAL OF NEUROINTERVENTIONAL SURGERY. HTTPS://DOI.ORG/10.1136/NEURINTSURG-2021-017832. AGE: THIS VALUE IS THE AVERAGE AGE OF THE PATIENTS REPORTED IN THE ARTICLE AS SPECIFIC PATIENTS COULD NOT BE IDENTIFIED. SEX: THIS VALUE REFLECTS THE GENDER OF THE MAJORITY OF THE PATIENTS REPORTED IN THE ARTICLE AS SPECIFIC PATIENTS COULD NOT BE IDENTIFIED. DATE OF EVENT: PLEASE NOTE THAT THIS DATE IS BASED OFF OF THE DATE OF PUBLICATION OF THE ARTICLE AS THE EVENT DATES WERE NOT PROVIDED IN THE PUBLISHED LITERATURE. IF INFORMATION IS PROVIDED IN THE FUTURE, A SUPPLEMENTAL REPORT WILL BE ISSUED.

Description of Event or Problem · 0

LIANG, F., MA, C., ZHU, H., LIU, L., LIANG, S., JIANG, P., ZHANG, Y., <(>&<)>AMP; JIANG, C. (2021). USING ANGIOGRAPHIC PARAMETRIC IM AGING-DERIVED RADIOMICS FEATURES TO PREDICT COMPLICATIONS AND EMBOLIZATION OUTCOMES OF INTRACRANIAL ANEURYSMS TREATED BY PIPELINE EMBOLIZATION DEVICES. JOURNAL OF NEUROINTERVENTIONAL SURGERY. HTTPS://DOI.ORG/10.1136/NEURINTSURG-2021-017832. SUMMARY: PIPELINE EMBOLIZATION DEVICES (PEDS) HAVE GAINED WIDESPREAD POPULARITY IN THE TREATMENT OF INTRACRANIAL ANEURYSMS (IAS). HOWEVER, PRECISE PREDICTORS OF TREATMENT OUTCOMES ARE STILL LACKING. THIS STUDY AIMED TO USE ANGIOGRAPHIC PARAMETRIC IMAGING (API)-DERIVED RADIOMICS FEATURES TO EXPLORE WHETHER BIOMARKERS EXTRACTED FROM IMMEDIATE POSTPROCEDURAL DIGITAL SUBTRACTION ANGIOGRAPHY (DSA) WERE ASSOCIATED WITH COMPLICATIONS AND EMBOLIZATION OUTCOMES OF IAS TREATED WITH PED WITHOUT ADJUNCTIVE COILS. IDENTIFIED EVENTS: THERE WERE 5 PATIENT DEATHS AS A RESULT OF EMBOLIZATION COMPLICATIONS. EVENT INFORMATION: THE MEAN MAXIMUM DIAMETER OF THE ANEURYSMS WAS 10.46±7.35MM. THE RATE OF ON-LABEL USE OF THE PED WAS 69.4%, INCLUDING 9.25% FOR CAVERNOUS CAROTID IAS, 55.16% FOR PARAOPHTHALMIC IAS, AND 4.98%14 FOR POSTERIOR COMMUNICATING ARTERY IAS. THE RATES OF OFF-LABEL USE OF THE PED WERE AS FOLLOWS: M1 AND M2 SEGMENTS OF THE MIDDLE CEREBRAL ARTERY IAS, 1.78% AND 0.71%, RESPECTIVELY; VERTEBROBASILAR IAS, 27.76%; AND P2 SEGMENT IAS, 0.36%. THE MAJORITY OF THE PATIENTS HAD ONE PED; NINE PATIENTS HAD TWO PEDS AND ONE PATIENT HAD FOUR PEDS. SACCULAR ANEURYSMS 155 (55.16%) NON-SACCULAR ANEURYSMS 126 (44.84%).

Description of Event or Problem · 0

LIANG, F., MA, C., ZHU, H., LIU, L., LIANG, S., JIANG, P., ZHANG, Y., <(>&<)>AMP; JIANG, C. (2021). USING ANGIOGRAPHIC PARAMETRIC IM AGING-DERIVED RADIOMICS FEATURES TO PREDICT COMPLICATIONS AND EMBOLIZATION OUTCOMES OF INTRACRANIAL ANEURYSMS TREATED BY PIPELINE EMBOLIZATION DEVICES. JOURNAL OF NEUROINTERVENTIONAL SURGERY. HTTPS://DOI.ORG/10.1136/NEURINTSURG-2021-017832. SUMMARY: PIPELINE EMBOLIZATION DEVICES (PEDS) HAVE GAINED WIDESPREAD POPULARITY IN THE TREATMENT OF INTRACRANIAL ANEURYSMS (IAS). HOWEVER, PRECISE PREDICTORS OF TREATMENT OUTCOMES ARE STILL LACKING. THIS STUDY AIMED TO USE ANGIOGRAPHIC PARAMETRIC IMAGING (API)-DERIVED RADIOMICS FEATURES TO EXPLORE WHETHER BIOMARKERS EXTRACTED FROM IMMEDIATE POSTPROCEDURAL DIGITAL SUBTRACTION ANGIOGRAPHY (DSA) WERE ASSOCIATED WITH COMPLICATIONS AND EMBOLIZATION OUTCOMES OF IAS TREATED WITH PED WITHOUT ADJUNCTIVE COILS. IDENTIFIED EVENTS: THERE WERE 5 PATIENT DEATHS AS A RESULT OF EMBOLIZATION COMPLICATIONS. EVENT INFORMATION: THE MEAN MAXIMUM DIAMETER OF THE ANEURYSMS WAS 10.46±7.35MM. THE RATE OF ON-LABEL USE OF THE PED WAS 69.4%, INCLUDING 9.25% FOR CAVERNOUS CAROTID IAS, 55.16% FOR PARAOPHTHALMIC IAS, AND 4.98%14 FOR POSTERIOR COMMUNICATING ARTERY IAS. THE RATES OF OFF-LABEL USE OF THE PED WERE AS FOLLOWS: M1 AND M2 SEGMENTS OF THE MIDDLE CEREBRAL ARTERY IAS, 1.78% AND 0.71%, RESPECTIVELY; VERTEBROBASILAR IAS, 27.76%; AND P2 SEGMENT IAS, 0.36%. THE MAJORITY OF THE PATIENTS HAD ONE PED; NINE PATIENTS HAD TWO PEDS AND ONE PATIENT HAD FOUR PEDS. SACCULAR ANEURYSMS 155 (55.16%) NON-SACCULAR ANEURYSMS 126 (44.84%).

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
111384 PIPELINE INTRACRANIAL ANEURYSM FLOW DIVERTER OUT MICRO THERAPEUTICS, INC. DBA EV3 NV UNK PIPELINE UNKNOWN

Patients

Seq Age Sex Outcome Treatment
1 53 YR Female Death