FDA Adverse Event Malfunction Summary report: N

GEENEN PANCREATIC STENT

MDR report key: 10605594 · Received September 30, 2020

Report

Report Number
3001845648-2020-00693
Event Type
Malfunction
Date Received
September 30, 2020
Date of Event
August 23, 2009
Report Date
July 29, 2022
Manufacturer
COOK IRELAND LTD
Product Code
FGE
PMA / PMN Number
K900923
Adverse Event
Yes
Product Problem
Yes
Report Source
Manufacturer report
Reporter Occupation
PHYSICIAN
Health Professional
Yes

Narratives

Additional Manufacturer Narrative · 0

DEVICE EVALUATION THE GEENEN PANCREATIC STENT OF UNKNOWN LOT NUMBER AND RPN INVOLVED IN THIS COMPLAINT WAS NOT AVAILABLE FOR EVALUATION. WITH THE INFORMATION PROVIDED, A DOCUMENT-BASED INVESTIGATION WAS CONDUCTED. THIS FILE WAS CREATED FROM THE ATTACHED JOURNAL ARTICLE "DIFFICULT BILIARY CANNULATION: USE OF PHYSICIAN-CONTROLLED WIRE-GUIDED CANNULATION OVER A PANCREATIC DUCT STENT TO REDUCE THE RATE OF PRECUT" (COTE ET AL 2009). COMPLAINT FILES (B)(4). (REPORT REFERENCE NUMBER 3001845648-2020-00692) AND PR309265 (REPORT REFERENCE NUMBER 3001845648-2020-00693) WERE OPENED AS A RESULT OF THIS PAPER. THIS FILE COVERS THE CASES OF MILD POST - ERCP PANCREATITIS DUE TO OFF-LABEL USE. (RPN UNKNOWN) PR309254 COVERS THE OFF LABEL USE OF GEENEN PANCREATIC STENT TO FACILITY BILIARY CANNULATION. (RPN UNKNOWN) DOCUMENT REVIEW AS THE RPN AND LOT NUMBER OF THE COMPLAINT DEVICES ARE UNKNOWN, A REVIEW OF THE RELEVANT MANUFACTURING RECORDS CANNOT BE CONDUCTED. HOWEVER, PRIOR TO DISTRIBUTION ALL GEENEN PANCREATIC STENT DEVICES ARE SUBJECTED TO A VISUAL INSPECTION AND FUNCTIONAL CHECKS TO ENSURE DEVICE INTEGRITY. THESE INSPECTIONS AND FUNCTIONAL CHECKS ARE OUTLINED IN INTERNAL PROCEDURES IN PLACE AT CIRL. THE INSTRUCTIONS OF USE (IFU0055-4) WHICH WOULD ACCOMPANY THIS DEVICE INSTRUCTS THE USER TO ¿VISUALLY INSPECT WITH PARTICULAR ATTENTION TO KINKS, BENDS AND BREAKS. IF AN ABNORMALITY IS DETECTED THAT WOULD PROHIBIT PROPER WORKING CONDITION, DO NOT USE.¿ IT SHOULD BE NOTED THAT THE DEVICE WAS USED OFF-LABEL, OUTSIDE ITS INTENDED USE STATED IN THE INSTRUCTIONS FOR USE (IFU0055-4) "THIS DEVICE IS USED TO DRAIN OBSTRUCTED PANCREATIC DUCTS" AND IN THE NOTES SECTION ¿DO NOT USE THIS DEVICE FOR ANY PURPOSE OTHER THAN STATED INTENDED USE.¿ THERE WERE 4 PATIENTS (5.3%) CASES OF MILD POST-ERCP PANCREATITIS, 2 OF WHICH OCCURRED IN PATIENTS WHO HAD THEIR PD STENT REMOVED AT THE COMPLETION OF THE PROCEDURE. ROOT CAUSE REVIEW A DEFINITIVE ROOT CAUSE CAN BE ATTRIBUTED TO THE OFF-LABEL USE OF THE DEVICE, WHEN THE DEVICE IS OUTSIDE ITS STATED INTENDED USE IT MAY LEAD TO OUTCOMES THAT WERE NEVER INTENDED TO HAPPEN AND WERE NEVER STUDIED. AS PER CLINICAL INPUT RECEIVED, THE PANCREATITIS THAT OCCURRED CAN BE ATTRIBUTED TO THE ERCP (ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY) PROCEDURE THAT OCCURRED, THIS IS REGARDED AS OFF-LABEL USE. SUMMARY COMPLAINT IS CONFIRMED BASED ON CUSTOMER TESTIMONY. ACCORDING TO THE INFORMATION RECEIVED THERE WERE 4 (5.3%) CASES OF MILD POST-ERCP PANCREATITIS, 2 OF WHICH WERE COMPLICATED BY BLEEDING DURING THE PROCEDURE. BLEEDING WAS SUCCESSFULLY CONTROLLED WITH SUBMUCOSAL INJECTION OF EPINDEPHRINE, NO OTHER PROCEDURE-RELATED COMPLICATIONS WERE IDENTIFIED.

Additional Manufacturer Narrative · 0

INVESTIGATION IS STILL PENDING, A FOLLOW UP MDR WILL BE SUBMITTED TO INCLUDE THE INVESTIGATION CONCLUSIONS.

Additional Manufacturer Narrative · 0

DEVICE EVALUATION THE GEENEN PANCREATIC STENT OF UNKNOWN LOT NUMBER AND RPN INVOLVED IN THIS COMPLAINT WAS NOT AVAILABLE FOR EVALUATION. WITH THE INFORMATION PROVIDED, A DOCUMENT-BASED INVESTIGATION WAS CONDUCTED. THIS FILE WAS CREATED FROM THE ATTACHED JOURNAL ARTICLE "DIFFICULT BILIARY CANNULATION: USE OF PHYSICIAN-CONTROLLED WIRE-GUIDED CANNULATION OVER A PANCREATIC DUCT STENT TO REDUCE THE RATE OF PRECUT". COMPLAINT FILES (B)(4) (3001845648-2020-00692) AND (B)(4) (3001845648-2020-00693) WERE OPENED AS A RESULT OF THIS PAPER. THIS FILE COVERS THE CASES OF MILD POST - ERCP PANCREATITIS. (RPN UNKNOWN) (B)(4) COVERS THE OFF LABEL USE OF GEENEN PANCREATIC STENT TO FACILITY BILIARY CANNULATION. (RPN UNKNOWN) DOCUMENT REVIEW AS THE RPN AND LOT NUMBER OF THE COMPLAINT DEVICES ARE UNKNOWN, A REVIEW OF THE RELEVANT MANUFACTURING RECORDS CANNOT BE CONDUCTED. HOWEVER, PRIOR TO DISTRIBUTION ALL GEENEN PANCREATIC STENT DEVICES ARE SUBJECTED TO A VISUAL INSPECTION AND FUNCTIONAL CHECKS TO ENSURE DEVICE INTEGRITY. THE INSTRUCTIONS OF USE (IFU0055-4) WHICH WOULD ACCOMPANY THIS DEVICE INSTRUCTS THE USER TO ¿VISUALLY INSPECT WITH PARTICULAR ATTENTION TO KINKS, BENDS AND BREAKS. IF AN ABNORMALITY IS DETECTED THAT WOULD PROHIBIT PROPER WORKING CONDITION, DO NOT USE.¿ IT SHOULD BE NOTED THAT THE DEVICE WAS USED OFF-LABEL, OUTSIDE ITS INTENDED USE STATED IN THE INSTRUCTIONS FOR USE (IFU0055-4) "THIS DEVICE IS USED TO DRAIN OBSTRUCTED PANCREATIC DUCTS" AND IN THE NOTES SECTION ¿DO NOT USE THIS DEVICE FOR ANY PURPOSE OTHER THAN STATED INTENDED USE.¿ THERE WERE 4 PATIENTS (5.3%) CASES OF MILD POST-ERCP PANCREATITIS, 2 OF WHICH OCCURRED IN PATIENTS WHO HAD THEIR PD STENT REMOVED AT THE COMPLETION OF THE PROCEDURE. ROOT CAUSE REVIEW A DEFINITIVE ROOT CAUSE COULD NOT BE DETERMINED FROM THE AVAILABLE INFORMATION. A POSSIBLE ROOT CAUSE COULD BE ATTRIBUTED TO THE ERCP PROCEDURE CAUSING ERCP- ASSOCIATED PANCREATITIS. SUMMARY COMPLAINT IS CONFIRMED BASED ON CUSTOMER TESTIMONY. ACCORDING TO THE INFORMATION RECEIVED THERE WERE 4 (5.3%) CASES OF MILD POST-ERCP PANCREATITIS, 2 OF WHICH OCCURRED IN PATIENTS WHO HAD THEIR PD STENT REMOVED AT THE COMPLETION OF THE PROCEDURE. COMPLAINTS OF THIS NATURE WILL CONTINUE TO BE MONITORED FOR POTENTIAL EMERGING TRENDS.

Description of Event or Problem · 0

SUPPLEMENTAL REPORT BEING SUBMITTED TO REPORT UPDATES TO THE FILE ON (B)(6) 2022.

Description of Event or Problem · 0

ADDITIONAL INFORMATION: CLINICAL INPUT CONFIRMS ON (B)(6) 2021 THAT PANCREATITIS WAS NOT CAUSED CONTRIBUTED BY STENT, THIS FILE NO LONGER MEETS THE REQUIREMENTS OF ¿SERIOUS INJURY¿ REPORT AS PER FDA GUIDELINES ¿MEDICAL DEVICE REPORTING FOR MANUFACTURERS (2016)¿ SECTION 2.13 AND 2.15. THIS SUPPLEMENT REPORT IS BEING MADE TO AMEND THE PREVIOUS REPORT SUBMITTED TO A MALFUNCTION REPORT TO CAPTURE OFF LABEL USE OF THE DEVICE.

Description of Event or Problem · 0

SUPPLEMENTAL REPORT IS BEING SUBMITTED DUE TO THE COMPLETION OF THE INVESTIGATION.

Additional Manufacturer Narrative · 1

INVESTIGATION IS STILL PENDING, A FOLLOW UP MDR WILL BE SUBMITTED TO INCLUDE THE INVESTIGATION CONCLUSIONS.

Description of Event or Problem · 1

COTE ET AL 2009 (GEENEN PS) ¿ ¿DIFFICULT BILIARY CANNULATION: USE OF PHYSICIAN-CONTROLLED WIRE-GUIDED CANNULATION OVER A PANCREATIC DUCT STENT TO REDUCE THE RATE OF PRECUT¿. THE PRIMARY OUTCOME WAS THE RATE OF SUCCESSFUL BILIARY CANNULATION WITHOUT PERFORMING A PRECUT SPHINCTEROTOMY. IF BILIARY CANNULATION IS UNSUCCESSFUL, THE PD IS CANNULATED AND A 0.025- OR 0.035-INCH GUIDEWIRE IS ADVANCED TO THE LEVEL OF THE MID PANCREATIC BODY TO ALLOW PLACEMENT OF A SOFT POLYETHYLENE STENT. THE TYPE OF STENT IS LEFT TO THE DISCRETION OF THE ENDOSCOPIST, EITHER A 4F (IF USING A 0.025-INCH WIRE) OR 5F STENT WITH AN EXTERNAL PIGTAIL AND SINGLE INTERNAL FLANGE (FREEMAN PANCREATIC STENT; HOBBS MEDICAL INC, STAFFORD SPRINGS, CONN) OR A 5F STENT WITH A DOUBLE EXTERNAL AND SINGLE INTERNAL FLANGE (GEENEN PANCREATIC STENT; COOK MEDICAL, BLOOMINGTON, IND). THE INTERNAL FLANGE IS OCCASIONALLY REMOVED TO PROMOTE SPONTANEOUS PASSAGE OF THE STENT AFTER THE PROCEDURE. A PANCREATIC SPHINCTEROTOMY WAS NOT PERFORMED BEFORE DEPLOYING THE PD STENT. THE STENT MAY BE DEPLOYED BY USING THE SPHINCTEROTOME AS A PUSHER. ONCE THE STENT IS ADVANCED TO ITS DESIRED POSITION, THE WIRE IS PULLED BACK INTO THE SPHINCTEROTOME AND ATTEMPTS AT BILIARY CANNULATION RESUME. PHYSICIAN-CONTROLLED WGC OF THE BILE DUCT IS THEN ATTEMPTED OVER THE PD STENT. IF CANNULATION IS UNSUCCESSFUL AFTER SEVERAL MINUTES, A PRECUT SPHINCTEROTOMY IS PER-FORMED OVER THE PD STENT OR THE PROCEDURE IS TERMINATED AND THE PATIENT RESCHEDULED FOR ANOTHER ATTEMPT. 5F GEENEN (COOK MEDICAL) (N = 31). THERE WERE 4 (5.3%) CASES OF MILD POST-ERCP PANCREATITIS, 2 OF WHICH OCCURRED IN PATIENTS WHO HAD THEIR PD STENT REMOVED AT THE COMPLETION OF THE PROCEDURE. THIS FILE IS ALSO RELATED TO OFF LABEL USE AS THE DEVICE WAS USED TO FACILITATE BILIARY CANNULATION & POTENTIALLY ALTERING THE SHAPE OF THE STENT "THE INTERNAL FLANGE IS OCCASIONALLY REMOVED TO PROMOTE SPONTANEOUS PASSAGE OF THE STENT AFTER THE PROCEDURE"

Devices

Seq Brand Generic Product Code Manufacturer Model Lot UDI-DI
1072314 GEENEN PANCREATIC STENT FGE CATHETER, BILIARY, DIAGNOSTIC FGE COOK IRELAND LTD UNKNOWN

Patients

Seq Age Sex Outcome Treatment
1 63 YR Female Required Intervention