Human Papillomavirus (HPV) Typing Detection Kit ( Reversible Terminator Sequencing)

Primary DI

06974968583216

Basic UDI-DI Code

B-06974968583216

Reference

L000047

Device Types

None provided

Regulation

Eu Ivdd

Classification

Eu Ivd General

Status

On The Market

Manufacturer

GeneMind Biosciences Co., Ltd.

Belonging to the Papillomaviridae family, human papillomavirus (HPV) is a kind of cyclic dsDNA virus in small molecule without coating by tunica. With a rough length of 8000 bp, the genome is divided into 3 functional spacers, namely early stage transcribed spacer (E spacer), late stage transcribed spacer (L spacer), and non-transcribed spacer (long control region, LCR). Human can be infected by HPV directly or indirectly through contacting contaminants or sexually transmitted infection. Featured with not only the host specificity, but also the tissue specificity, this virus can only infect epithelial cells of human skin and mucosa, resulting in skin varied of papilloma or verruca, and genital tract epithelial hyperplasia injury. HPV commonly infects the genital tract of females who have a sex life. According to the statistics, 70%-80% of females have at least one infection in their lives. However, most of them belong to a self-limiting infection. More than 90% of infected females developed an effective immune response, whose infection can be cleared within 6-24 months in the absence of any long-term health intervention. However, continuous high risk HPV infection is the major cause resulting in cervical intraepithelial neoplasia and cervix carcinoma. Results of global researches show that high risk HPV DNA has been detected in the body of 99.7% of cervix carcinoma patients. Generally, low risk HPV is related to condyloma acuminatum lesion or low grade squamous intraepithelial lesions, rarely resulting in infiltrating carcinoma. Due to lacking effective treatments generally accepted to HPV, and considering that the carcinoma lesion can develop into two directions (development and reversion) at any period before developing to infiltrating carcinoma, early detection and prevention from high risk HPV are the key to blocking carcinoma lesion

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